Anopheles mosquito midgut harbors a diverse group of endogenous bacteria that grow extensively after the blood feeding and help in food digestion and nutrition in many ways. Although, the growth of endogenous bacteria is regulated by various factors, however, the robust antibacterial immune reactions are generally suppressed in this body compartment by a heme peroxidase HPX15 crosslinked mucins...

Intestinal epithelial renewal is mediated by intestinal stem cells (ISCs) that exist in a state of neutral drift, wherein individual ISC lineages are regularly lost and born but ISC numbers remain constant. To test whether an active mechanism maintains stem cell pools in the Drosophila midgut, we performed partial ISC depletion. In contrast to the mouse intestine, Drosophila ISCs failed to repo...

Midgut malrotation (MMR) is the abnormal rotation of the foetal midgut around the axis of the superior mesenteric artery which in symptomatic neonates requires a Ladd's procedure. We present a rare case of midgut volvulus occurring in a teenager 3 days after observational management of incidentally discovered MMR during laparoscopic appendectomy. A Ladd's procedure was performed and the patient...

The midgut contents of lepidopteran larvae are often several pH units more basic than the haemolymph (Berenbaum, 1980). One species, Manduca sexta, maintains a luminal pH of 11.3 (Dow, 1984) while the haemolymph has a pH of 6.7-6.8 (Dow, 1984; Dow et al. 1984). The midgut of M. sexta is divided into three morphologically distinct regions (Cioffi, 1979), and Dow (1984) has shown that the luminal...

Periplocoside NW (PSNW) is a novel insecticidal compound isolated from the root bark of Periploca sepium Bunge and has potent stomach toxicity against some insect pests. Previous studies showed that the Mythimna separata larva is sensitive to PSNW, but the Agrotis ispilon larva is insensitive. In this study, preliminary target localization on the midgut of M. separata larvae was conducted via a...

Two integrin beta subunits are encoded in the Drosophila genome. The betaPS subunit is widely expressed and heterodimers containing this subunit are required for many developmental processes. The second betasubunit, betanu, is a divergent integrin expressed primarily in the midgut endoderm. To elucidate its function, we generated null mutations in the gene encoding betanu. We find that betanu i...

Normal embryonic intestinal rotations were first described by Mall in 1898 [1]. In 1923, Dott, published the article about abnormalities of rotation and fixation with their surgical aspects [2]. Classic Ladd's procedure as an academic operative technique to treat midgut volvulus was introduced in 1936 by himself [3]. The true incidence of malrotation of the midgut is unknown because the spectru...