MicroRNAs (miRNAs) are short endogenous RNAs known to post-transcriptionally repress gene expression in animals and plants. A microarray profiling survey revealed the expression patterns of 175 human miRNAs across 24 different human organs. Our results show that proximal pairs of miRNAs are generally coexpressed. In addition, an abrupt transition in the correlation between pairs of expressed mi...

MicroRNAs play important regulatory roles in eukaryotic lineages. In this paper, we employed deep sequencing technology to sequence and identify microRNAs in M. incognita genome, which is one of the important plant parasitic nematodes. We identified 102 M. incognita microRNA genes, which can be grouped into 71 nonredundant miRNAs based on mature sequences. Among the 71 miRANs, 27 are known miRN...

Diabetic retinopathy (DR) accounts for ~80% of legal blindness in persons aged 20-74 years and is associated with enormous social health burdens. Current therapies are invasive, non-curative, in-effective 15-25% DR patients. This review outlines the potential utility microRNAs (miRNAs) as biomarkers therapy diabetic retinopathy. miRNAs small noncoding forms RNA that may play a role pathogenesis...

The scientific review presents the mechanisms of action intranuclear miRNAs, namely microRNA-mediated regulation non-coding RNA (ncRNA) transcriptome and alternative splicing. To write article, information was searched using Scopus, Web Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, Cochrane Library, CyberLeninka databases. It is emphasized that a significant effect on composi...

MicroRNAs (miRNAs) are small regulatory molecules that involved in posttranscriptional modifications. These noncoding RNAs usually ferried by extracellular carriers such as exosomes or other protein and lipid inside a range of body fluids including plasma urine. Due to their ability withstand harsh external conditions, exosomal miRNAs possess enormous potential noninvasive disease biomarkers fo...

MicroRNAs (miRNAs) are a class of small (approx. 22 nt) noncoding RNAs that are capable of post-transcriptionally silencing mRNAs that contain sequences complementary to the miRNAs’ 7to 8-bp ‘seed’ sequence. As single miRNAs are often predicted to target up to hundreds of individual transcripts, miRNAs are able to broadly affect the overall protein expression state of the cell. This can transla...

MicroRNAs a category of noncoding RNA dysregulations are involved in numerous pathological conditions including cancer, diabetes, heart diseases, immunological disorders, neurological diseases and many metabolic diseases. Advancement the knowledge microRNA applications led to diagnosis some early markers Currently innovative molecular biotechnology is holding promising future field application ...

objective: prostate cancer is the fifth most common cancer. in 2012, it was the second leading cause of cancer death for men worldwide. the pi3k/akt pathway plays an essential role in pathogenesis of prostate cancer; the key role of this pathway in cancer progression makes it an attractive target for prostate cancer therapy. micrornas (mirnas) that regulate gene expression have a special abilit...

Cardiac arrhythmias are prevalent among humans across all age ranges, affecting millions of people worldwide. While cardiac vary widely in their clinical presentation, they possess shared complex electrophysiologic properties at cellular level that have not been fully studied. Over the last decade, our current understanding functional roles non-coding RNAs progressively increased. microRNAs rep...

MicroRNAs (miRNAs) regulate cell fate during development and in response to environmental cues. Here, we review the emerging story of how miRNAs regulate immune cell development and function.