This paper reports on the feasibility of using surface mount technology (SMT) assembly processes and materials to produce highly parallel, high-aspect ratio microchannel arrays. Experimental results show that the fabrication of high-aspect-ratio (> 40:1) microchannel arrays is possible using solder paste, screen printing, and reflow bonding. A simple model and empirical examination verifies tha...

We demonstrate an improved femtosecond laser irradiation followed by chemical etching process to create complex three-dimensional (3D) microchannels with arbitrary length and uniform diameter inside fused silica. A segmented chemical etching method of introducing extra access ports and a secondary power compensation is presented, which enables the fabrication of uniform 3D helical microchannels...

Magnetically functionalized PDMS-based micropillar arrays have been successfully designed, fabricated and implanted for controllable microfluidic mixing. The arrangement of PDMS micropillar arrays inside the microchannel can be flexibly controlled by an external magnetic field. As a consequence, the flow fields inside the microchannel can be regulated at will via magnetic activation convenientl...

Abstract: Effective and rapid mixing is essential for various chemical and biological assays. The present work reports a simple and low-cost micromixer based on magnetofluidic actuation. The device takes advantage of magnetoconvective secondary flow, a bulk flow induced by an external magnetic field, for mixing. A paramagnetic stream of diluted ferrofluid and a non-magnetic stream are introduce...

Highly effective mixing in microchannels is important for most chemical reactions conducted in microfluidic chips. To obtain a rigid and chemically resistant micromixer system at low cost, we fabricated a Y-shaped microchannel with built-in mixer structures by static liquid photolithography (SLP) from methacrylated polyvinylsilazane (MPVSZ) as an inorganic polymer photoresist which was then con...

This study develops a hybrid numerical scheme based on a molecular dynamics (MD) algorithm and the GROMACS protein data bank to analyze the thermal bio-flow of alanine molecules in a microchannel. The numerical results show that the velocity profiles in the microchannel are highly dependent on both global effects, i.e. the effective channel width and local effects, i.e. the thermal boundary con...

......................................................................................................................... viii CHAPTER 1. GENERAL INTRODUCTION ..................................................................... 1 Microchannels in Biomedical Devices .................................................................................. 1 Research Motivation ............................

This paper analyzes compressible gaseous flow through a three-dimensional straight uniform rectangular microchannel, and reports a set of asymptotic solutions. This work represents an extension of previous work on compressible flows through a two-dimensional microchannel. First, we choose the ratio of Dh/L as the small expansion parameter, where Dh and L are the channel’s hydrodynamic diameter ...

MATERIALS AND METHODS: Pluronic F127 fibers, 1.5 mm in diameter, were sacrificed in type I collagen, creating a central looped microchannel. 100μL polyculture cell suspension mixture of 5 x 10 cells/mL of human foreskin fibroblasts and 5 x 10 cells/mL of human aortic smooth muscle cells was seeded into the microchannel. The following day, a 100μL cell suspension of 5 x 10 cells/mL of human plac...

Secondary flow plays a critical function in a microchannel, such as a micromixer, because it can enhance heat and mass transfer. However, there is no experimental method to visualize the secondary flow and the associated mixing pattern in a microchannel because of difficulties in high-resolution, non-invasive, cross-sectional imaging. Here, we simultaneously imaged and quantified the secondary ...