Experimental evaluation of a diffusion reaction model (part 1) for the determination of both steady-and transient-state behavior of biofilters for waste air biotreatment is presented. The model, applied to the aerobic biodegradation of methyl ethyl ketone (MEK) and methyl isobutyl ketone (MIBK) vapors from air as single and as mixed pollutants, proved appropriate for describing most of the expe...

Five new bulky moiety-modified analogues of the sandalwood odorant Polysantol have been synthesized by aldol condensation of appropriate aldehydes with butanone, deconjugative alpha-methylation of the resulting alpha,beta-unsaturated ketones, and reduction of the corresponding beta,gamma-unsaturated ketones. The final compounds were evaluated organoleptically and one of them seemed to be of spe...

BACKGROUND Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain tumors. The KD targets tumor energy metabolism by lowering blood gl...

1. Seven patients with acromegaly and nine controls were studied before, during and after 30 min of moderate steady exercise on a bicycle ergometer. Venous blood samples were taken for estimation of growth hormone (HGH), immunoreactive insulin (IRI), pyruvate, lactate, glucose, free fatty acids (FFA), glycerol and ketone bodies. 2. Exercise caused a rise in HGH concentrations in the acromegalic...

Antiviral activity of rabbit and mouse fibroblast interferons was irreversibly destroyed by treatment with halomethyl ketone derivatives of phenylalanine but not by treatment with a halomethyl ketone derivative of lysine. The inactivation reaction was pH dependent, suggesting the involvement of an amino acid residue ionizing in the region of pH 7. Tryptophan and phenylalanine, known ligands of ...

Front cover: In article 2200704 by Dmitrii Rusakov, Angelika Menner, and Alexander Bismarck, a high-temperature process with two high boiling point solvents allows to successfully create porous poly(ether ketone ketone) (PEKK) tunable properties, making it promising material for biomedical applications. The achieved porosities of 70 90%, specific surface areas up 194 m2 g−1, adjustable elastic ...

Carboxylesterases are important enzymes responsible for the hydrolysis and metabolism of numerous pharmaceuticals and xenobiotics. These enzymes are potently inhibited by trifluoromethyl ketone containing (TFK) inhibitors. We demonstrated that the ketone hydration state was affected by the surrounding chemical moieties and was related to inhibitor potency, with inhibitors that favored the gem-d...