Mushroom derived phytochemical has become the promising agent to treat inflammatory bowel disease (IBD). Here, we investigated effect of flavonoids from <i>Agrocybe aegirita</i> (AAF) on dextran sodium sulfate-induced colitis. Our results showed that had a certain physical signs in mice (improving weight loss mice, reducing DAI index and spleen mice). AAF could also significantly re...

Background: Recent evidence suggests that regular exercise training is effective in treating various aspects of cancer. Therefore, the purpose of this study was to determine the effect of 8 weeks of aerobic interval training on monocarboxylate transporter 1 (MCT1) protein and expression of p53 gene in tumor of colon cancer mice. Methods: The present study was conducted experimentally from May ...

Our previous study has demonstrated that the exposure of male BALB/c mice to social isolation stress caused a suppressed immune response and enhanced liver metastasis of colon 26-L5 carcinoma cells. To more precisely understand the influence of psychosocial factors on the metastatic process, here we have investigated the effect of social isolation stress on the vulnerability of the host to deve...

We have investigated the expression of the protooncogenes of the myc and ras family in HT29 cells and in three differentiated clonal cell lines derived from this colon carcinoma cell line. In contrast to the decrease in myc expression seen when leukemia cells are induced to differentiate, we have found no changes in expression of the myc gene family in differentiated colon carcinoma cells. Howe...

Introduction: In Croatia, about 3,500 patients are diagnosed with a colorectal carcinoma annually. The National Program for Early Detection of Colon Cancer has been implemented in Croatia since 2007. program’s primary goal is todetect colon cancer at an early stage the disease, which should reduce incidence and mortality from cancer. Aim: To determine interest target group participating program...

Introduction: We report a case of a 64-year old man with a history of colon carcinoma. He underwent fine-needle aspiration by CytoFoam-core and diagnosis of metastatic colon cancer to the thyroid gland. Case presentation: In this case report, a solid thyroid nodule in the right lobe of a 64-year-old male was aspirated. The cytological smears showed a small group of atypical cells with the obvi...

Introduction: We report a case of a 64-year old man with a history of colon carcinoma. He underwent fine-needle aspiration by CytoFoam-core and diagnosis of metastatic colon cancer to the thyroid gland. Case presentation: In this case report, a solid thyroid nodule in the right lobe of a 64-year-old male was aspirated. The cytological smears showed a small group of atypical cells with the obvi...

Although, 5-Fluorouracil (5-FU) remains widely used in adjuvant therapy in patients with colon cancer, resistance to 5-FU-based chemotherapy is an important reason for treatment failure. Recent studies have reported that an enhanced reactive oxygen species (ROS) scavenging system shows drug resistance to 5-FU. Peroxiredoxin-2 (PRDX2), is an important member of the ROS scavenging system, and may...

We have recently reported that evodiamine can suppress in vitro invasion and lung metastasis by colon 26-L5 carcinoma cells. To extend our study, we examine here the anti-invasive and metastatic effects of evodiamine on Lewis lung carcinoma (LLC) and B16-F10 melanoma in addition to colon 26-L5 carcinoma. Critical structures of evodiamine for the activities were also evaluated by comparison with...

Intravenous (iv) infusion of high-dose ascorbic acid (AA) has been used as a treatment for cancer patients. The tumoricidal action of AA occurs due to its prooxidant effect. Erythorbic acid (EA), one of the AA epimers, has reduced vitamin C activity, while the antioxidant activity of EA is similar to that of AA. Currently, other physiological and pharmacological functions of EA are not well kno...