نتایج جستجو برای: mhc i

تعداد نتایج: 1050459  

Journal: :The Journal of Cell Biology 1997
Søren Skov Pia Klausen Mogens H. Claesson

Ligation of major histocompatability complex class I (MHC-I) molecules expressed on T cells leads to both growth arrest and apoptosis. The aim of the current study was to investigate the intracellular signal pathways that mediate these effects. MHC-I ligation of human Jurkat T cells induced a morphologically distinct form of apoptosis within 6 h. A specific caspase inhibitor, which inhibited Fa...

Journal: :Journal of cellular physiology 2012
Gordana Blagojević Zagorac Hana Mahmutefendić Maja Ilić Tomaš Natalia Kučić Philippe Le Bouteiller Pero Lučin

Major histocompatibility class I (MHC-I) molecules are present at the cell surface both as fully conformed trimolecular complexes composed of heavy chain (HC), beta-2-microglobulin (β2m) and peptide, and various open forms, devoid of peptide and/or β2m (open MHC-I conformers). Fully conformed MHC-I complexes and open MHC-I conformers can be distinguished by well characterized monoclonal antibod...

Journal: :The Biochemical journal 2003
Sandra I Kim Amanda Pabon Todd A Swanson Marc J Glucksman

Endopeptidase EP24.15 (EC 3.4.24.15; thimet oligopeptidase), traditionally classified as a neuropeptide-processing enzyme, degrades well-known MHC I (major histocompatibility complex class I) peptides in cell extracts. In the present study, we determine the contribution of EP24.15 in vivo to the surface expression of MHC I on intact cells. CTLs (cytotoxic T-lymphocytes) recognize a vast array o...

2010
Jimmy D. Dikeakos Katelyn M. Atkins Laurel Thomas Lori Emert-Sedlak In-Ja L. Byeon Jinwon Jung Jinwoo Ahn Matthew D. Wortman Ben Kukull Masumichi Saito Hirokazu Koizumi Danielle M. Williamson Masateru Hiyoshi Eric Barklis Masafumi Takiguchi Shinya Suzu Angela M. Gronenborn Thomas E. Smithgall Gary Thomas

HIV-1 Nef triggers down-regulation of cell-surface MHC-I by assembling a Src family kinase (SFK)-ZAP-70/Syk-PI3K cascade. Here, we report that chemical disruption of the Nef-SFK interaction with the small molecule inhibitor 2c blocks assembly of the multi-kinase complex and represses HIV-1-mediated MHC-I down-regulation in primary CD4(+) T-cells. 2c did not interfere with the PACS-2-dependent t...

2014
Weerachai Jaratlerdsiri Janine Deakin Ricardo M. Godinez Xueyan Shan Daniel G. Peterson Sylvain Marthey Eric Lyons Fiona M. McCarthy Sally R. Isberg Damien P. Higgins Amanda Y. Chong John St John Travis C. Glenn David A. Ray Jaime Gongora

The major histocompatibility complex (MHC) is a dynamic genome region with an essential role in the adaptive immunity of vertebrates, especially antigen presentation. The MHC is generally divided into subregions (classes I, II and III) containing genes of similar function across species, but with different gene number and organisation. Crocodylia (crocodilians) are widely distributed and repres...

Journal: :The Journal of Experimental Medicine 2003
Lélia Delamarre Hilda Holcombe Ira Mellman

During maturation, dendritic cells (DCs) regulate their capacity to process and present major histocompatibility complex (MHC) II-restricted antigens. Here we show that presentation of exogenous antigens by MHC I is also subject to developmental control, but in a fashion strikingly distinct from MHC II. Immature mouse bone marrow-derived DCs internalize soluble ovalbumin and sequester the antig...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Syed Monem Rizvi Malini Raghavan

Tapasin (Tpn) has been implicated in multiple steps of the MHC class I assembly pathway, but the mechanisms of function remain incompletely understood. Using purified proteins, we could demonstrate direct binding of Tpn to peptide-deficient forms of MHC class I molecules at physiological temperatures. Tpn also bound to M10.5, a pheromone receptor-associated MHC molecule that has an open and emp...

2009
Rajendra Kumar Singh David Lau Colleen M. Noviello Partho Ghosh John C. Guatelli

BACKGROUND The down-regulation of the major histocompatibility complex class I (MHC-I) from the surface of infected cells by the Nef proteins of primate immunodeficiency viruses likely contributes to pathogenesis by providing evasion of cell-mediated immunity. HIV-1 Nef-induced down-regulation involves endosomal trafficking and a cooperative interaction between the cytoplasmic domain (CD) of MH...

Journal: :Journal of immunology 2010
Ralf M Leonhardt Dorothee Fiegl Elke Rufer Axel Karger Barbara Bettin Michael R Knittler

The function of the peptide-loading complex (PLC) is to facilitate loading of MHC class I (MHC I) molecules with antigenic peptides in the endoplasmic reticulum and to drive the selection of these ligands toward a set of high-affinity binders. When the PLC fails to perform properly, as frequently observed in virus-infected or tumor cells, structurally unstable MHC I peptide complexes are genera...

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