Mutagenic activity was found in the urine of 10 patients given therapeutic dosages of metronidazole orally or per vagina. Paper chromatographic separation revealed that mutagenicity in the urine was associated with unmodified metronidazole and at least four of its known urinary metabolites. Activity was also recovered in a region of the chromatogram heretofore not assigned to a metronidazole me...

Helicobacter pylori resistance to metronidazole was detected in 107 (52.97%) of 202 strains. Twenty (9.85%) strains, 18 of them harboring 23S ribosomal DNA mutations, were resistant to clarithromycin. Metronidazole resistance was associated with female gender. Resistance to metronidazole and resistance to clarithromycin were associated. Increasing clarithromycin resistance rates were observed o...

Abstract Background Metronidazole is a widely used antibiotic to treat anaerobic and protozoal infections. However, neurologic adverse events associated with metronidazole have been reported in case series reports. Previous publications implicated that long-term usage cumulative dose are risk factors for this event. Still, little known about the factor of metronidazole-associated events. Theref...

The main objectives of this study were to determine whether the nitroreductase enzyme encoded by the rdxA gene of Helicobacter pylori was responsible for reductive activation of nitrofurantoin and whether a triple-therapy regimen with nitrofurantoin was able to eradicate metronidazole-sensitive and -resistant H. pylori infections from mice. The susceptibilities to nitrofurantoin of parent and i...

Metronidazole is a well-known antimicrobial agent, used for the treatment of anaerobic bacterial and protozoal infections. It generally well tolerated with common side effects like nausea, dizziness, headache metallic taste in mouth. But prolonged use metronidazole can cause neurotoxicity ataxic gait, dysarthria, seizures encephalopathy. Here, we are reporting case 60 years old male patient who...

Cerebellar ataxic syndromes, although uncommon, have been reported previously in patients taking metronidazole. However, almost all cases describe instances where were prolonged or high doses of the drug. We report a 65-year-old man who consumed 400 mg metronidazole 3 times over 1 day and presented with slurring speech, imbalance while walking diplopia. The symptoms developed after consumption ...

BACKGROUND AND AIMS The success of Helicobacter pylori eradication regimens depends on gastric pH, inflammation, and mucus thickness. Our aim was to investigate the effects of acid secretion, inflammation, and mucolysis on gastric antibiotic transfer. SUBJECTS AND METHODS A total of 134 anaesthetised rats were given metronidazole, amoxicillin, or clarithromycin intravenously and gastric conte...

A high prevalence of metronidazole resistance in Helicobacter pylorn is reported in developing countries. This study examined whether migrants referred for diagnostic gastroscopy at a United Kingdom centre (n= 54), had a higher prevalence of metronidazole resistance than subjects born in the United Kingdom attending endoscopy (n=46). Records of nitroimidazole treatment prescribed in the United ...

The prevalence of primary metronidazole resistance of Helicobacter pylori was studied in one Dutch hospital from 1993 to 1996 and in two additional Dutch hospitals in 1993 and 1996. All cultures of antral biopsy specimens yielding H. pylori in the study period were evaluated, except those from patients who had received anti-H. pylori treatment; 1,037 H. pylori strains, all from different patien...