In the title compound, [Ti2(C16H14N2O2)2O2]·2CHCl3, the Ti(IV) atom in the centrosymmetric complex has a distorted octa-hedral N2O4 coordination environment and is linked via two μ2-oxido bridges into a dinuclear centrosymmetric com-plex, with a Ti⋯Ti separation of 2.7794 (8) Å. In the salen (N,N'-ethyl-enebis(salicyl-imine)) ligand, the two salicyl-imine units make a dihedral angle of 45.31 (5...

Dacarbazine is an antitumor prodrug which is used for the treatment of malignant metastatic melanoma and Hodgkin’s disease. It requires initial activation in liver through an N-demethylationreaction. The active metabolite prevents the progress of disease via alkylation of guanine bases in DNA strands. In order to investigate the importance of imidazole ring and its dynamictautomerization in ant...

The phenyltetrel pyridine-2-olates PhE(pyO)3 (E = Si, Ge, Sn; pyO pyridine-2-olate) were synthesized from the respective chlorides PhECl3 and 2-hydroxypyridine (2-pyridone) with aid of a sacrificial base (triethylamine). Their solid-state structures determined by single-crystal X-ray diffraction. PhSi(pyO)3 exhibits three-fold capped tetrahedral Si coordination sphere ([4+3]-coordination, Si···...

We study simulated annealing techniques for crystal structure determination from diffraction data. We demonstrate that for this problem the efficiency of simulated annealing can be systematically improved by an iterative simulation protocol. Our approach is tested for the example of 9-(methylamino)-1 H-phenalen-1-one-1, 4-dioxan-2-yl hydroperoxide solvate (C18H19NO5).

We have isolated the stable as well as the metastable tautomers of 1-deazapurine in the solid state by exploiting principles of supramolecular selectivity in the context of cocrystal design.

The idea that the environmental toxin beta-N-methylamino-l-alanine (BMAA) is involved in neurodegenerative diseases on Guam has risen and fallen over the years. The theory has gained greater interest with recent reports that BMAA is biomagnified, is widely distributed around the planet, and is present in the brains of Alzheimer's patients in Canada. We provide two important new findings. First,...

hantzsch 1, 4-dihydropyridines (1,4-dhps) can be oxidized to the corresponding pyridine derivatives by thallium triacetate in high yields.

reaction of tryptamine 1 with dimethyl -3-methoxyallylidenemalonate 2 afforded n?-[4,4-bis (methoxycarbonyl)-1,3-butadienyl] tryptamine 3 which in combination with acetylchloride and pyridine in dichloromethane gave n?, n?-[acetyl]-[(4,4-dinethoxycarbonyl) 1,3butadienyl] tryptamine 4. treatment of 3 with sodium hydroxide afforded 2h[n-(3-indolyl) ethyl] 2-oxo-3-methoxycarbonyl-1-pyridine 5. cyc...

The reactions of isatins, 3-amino-1-pheyl-1H-pyrazol-5(4H)-one, and monocyclic ketones, have been developed for preparation spiro[indoline-3,4'-pyrazolo[3,4-b]quinoline]-2,3'(6'H)-dione, spiro[cyclohepta[b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2′,3-dione, spiro[cycloocta[b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2′,3(6H)-dione, spiro[cyclo dodeca[b]pyrazolo[4,3-e]pyridine-4,3'-indoline]-2′,3(6H...

In the last few years, imidazo[1,5-a]pyridine scaffolds and derivatives have attracted growing attention due to their unique chemical structure optical behaviors. this work, a series of pyridylimidazo[1,5-a]pyridine corresponding pyridinium salts were synthesized properties investigated evaluate effect quaternization on features both in solution polymeric matrix. A critical analysis based spect...