During the past few years a concerted effort has been made to develop synthetic derivatives of hydrocortisone and cortisone which would retain their anti-inflammatory activity but would be devoid of certain of their unwanted physiologic effects. Hope that analogues with enhanced therapeutic indices could be synthesized has stemmed from the knowledge that several properties of the naturally occu...

Intranasal route, ensuring suitable bioavailability of medicines under circumvention of the gastrointestinal degradation and hepatic first-pass elimination, has been a popular choice for drug delivery. Among nasal dosage forms, mucoadhesive solid inserts have been shown to resist mucociliary clearance and provide a prolonged nasal residence time. Hence, the purpose of this study was the prepara...

Microdochium patch is a destructive disease of amenity turfgrass caused by the fungus nivale (Fries) Samuels & I.C. Hallett. The succinate dehydrogenase (SDHI) class fungicides relatively new and their efficacy against M. remains unclear. Fluxapyroxad (3-(difluoromethyl)-1-methyl-N-[2-(3,4,5-trifluorophenyl)phenyl]pyrazole-4-carboxamide), penthiopyrad (1-methyl-N-[2-(4-methylpentan-2-yl)thiophe...

Abstract Background Clinical studies of anti-glomerular basement membrane (GBM) disease were limited because the low incidence. We aimed to report characteristics, treatments, and outcomes patients with anti-GBM at a tertiary reference medical center in Japan review literature mortality disease. Case presentation 1 was 72-year-old Japanese man that referred worsening serum creatinine (from 1.1 ...

The introduction of cortisone as an anti-inflammatory agent stimulated the search for newer steroids with greater anti-rheumatic effect, but with fewer associated side-reactions. Shortly afterwards, hydrocortisone became available, and, although its anti-rheumatic effect was slightly greater, undesirable physiological responses were more or less similar. Fried and Sabo (1953) synthesized a cort...

Pseudomonas fluorescens Pf0-1 exhibited chemotactic responses to l-malate, succinate, and fumarate. We constructed a plasmid library of 37 methyl-accepting chemotaxis protein (MCP) genes of P. fluorescens Pf0-1. To identify a MCP for l-malate, the plasmid library was screened using the PA2652 mutant of Pseudomonas aeruginosa PAO1, a mutant defective in chemotaxis to l-malate. The introduction o...

1. The following enzymes of the phosphorylated pathway of serine biosynthesis have been found in methanoland succinate-grown Pseudomona8 AM 1: phosphoglycerate dehydrogenase, phosphoserine-a-oxoglutarate aminotransferase and phosphoserine phosphohydrolase. Their specific activities were similar in the organism grown on either substrate. 2. A procedure for preparation of auxotrophic mutants of P...

A simple method of simultaneous analysis for chloramphenicol and chloramphenicol succinate in 10-microL samples of plasma is described. We injected the plasma samples directly into a radial-compression liquid chromatograph equipped with a precolumn module and a C18 insert. A mixture of acetic acid solution (pH 3)/acetonitrile (75/25, by vol) was used as mobile phase, at a flow rate of 4 mL/min....