A consideration of numerous studies in viva indicates that the metabolism of methionine, folic acid, and cyano-B1$ is interrelated. The vitamin has a sparing effect on the methyl group requirement of young chickens, and, conversely, methionine has a sparing effect on the cyano-Blz requirement in chickens and rats (l-4). A more direct demonstration of an impairment in methyl group biosynthesis d...

One of the most striking features of several X-ray structures of CoA-independent ALDHs (aldehyde dehydrogenases) in complex with NAD(P) is the conformational flexibility of the NMN moiety. However, the fact that the rate of the acylation step is high in GAPN (non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase) from Streptococcus mutans implies an optimal positioning of the nicotinamid...

A new class of enantiopure carbene precursors based on cheap camphor has been developed, and a restricted rotation of one N-substituent due to the C-10 methyl group of the camphor skeleton has been found; in situ prepared corresponding carbenes revealed the same behaviour.

The 5'-end structure of potato virus X RNA was determined following enzymatic methylation in vitro. A single 3H-methyl group was introduced into the 2'-position of the 5'-penultimate residue and the end structure was determined as m7GpppG(m)pAp(Xp)3G. This part of the RNA apparently is involved in binding to ribosomes since it can be partially protected against RNase digestion by wheat germ 40S...

The title phenyl-hydrazine derivative, C16H16N2O4, has a crystallographically imposed centre of symmetry. Except for the methyl group, all non-H atoms are almost coplanar (r.m.s. deviation = 0.0095 Å). Intra-molecular O-H⋯N hydrogen bonds are observed, generating S(6) graph-set ring motifs.

Among the handful of monophosphine ligands that effect asymmetric hydrovinylation of vinylarenes, 2-diphenylphosphino-2'-methoxy-1,1'-binaphthyl (MOP) is among the most accessible. Addition of a methyl group at the 3'-position of this ligand significantly improves the enantioselectivity of hydrovinylation of prototypical alkenes. Introduction of a chiral phospholane at the C2 position of this s...

In the title compound, C(16)H(12)Cl(2)O(2)S, the O atom and the methyl group of the methyl-sulfinyl substituent lie on opposite sides of the plane through the benzofuran fragment. The 4-chloro-phenyl ring is rotated out of the benzofuran plane, as indicated by the dihedral angle of 15.91 (4)°. In the crystal, mol-ecules are linked into chains along the b axis by weak inter-molecular C-H⋯O hydro...

Evidence is presented for a catabolic pathway of n-alkane oxidation which proceeds via subterminal oxidation rather than methyl group oxidation.

In the crystal structure of the title compound, C(6)H(7)N·CH(4)N(2)O, the 2-methyl-pyridine and urea mol-ecules are linked via N-H⋯O and N-H⋯N hydrogen bonds, forming ribbons extending along the a axis. The dihedral angle between the 2-methyl-pyridine and urea mean planes is 89.09 (9)°. The methyl group shows rotational disorder wherein the H atoms are located over two sets of sites with equal ...

In the title compound, [Rh(C(13)H(16)NO)(CO)(2)], a square-planar coordination geometry is observed around the Rh(I) atom, formed by the N and O atoms of the bidentate ligand and two C atoms from two carbonyl ligands. The Rh(I) atom is displaced from the plane through these surrounding atoms by 0.0085 (2) Å. The dihedral angle between the benzene ring and the N-C-C-C-O plane is 89.82 (6)°, and ...