background evidence indicates that insulin resistance results in poor sustained viral response (svr) in patients with chronic hepatitis c (chc). metformin is an oral hypoglycemic agent which improves insulin resistance. methods we sought to determine if the addition of metformin to the treatment regimen could improve svr in treatment-naive chc patients in a randomized, double-blind, placebo-con...

sepsis as the host responsive syndrome is one of the main concerning issues and costly disease on intensive care unit (icu) in the 21st century. epidemiological studies have showed that mortality rates of sepsis in icu and hospitals among 37 countries were 39.2% and 49.6% respectively [1].  complicated nature of sepsis is still not well understood and this makes it hard to treat and manage. acc...

Obesity, metabolic syndrome and type 2 diabetes are associated with cancer-related mortality. We assessed whether hyperinsulinemia is a risk factor for cancer death in nonobese people without diabetes. We conducted a prospective cohort study using data from the National Health and Nutrition Examination Survey 1999-2010 and followed up the participants until December 31, 2011. For the primary an...

STUDY QUESTION Does treatment with the insulin sensitizer metformin modify the levels and activation of proteins related to the expression of the insulin-dependent glucose transporter (GLUT4), such as adenosine monophosphate-activated protein kinase (AMPK) and myocyte enhancer factor 2A (MEF2A), in endometria from hyperinsulinemic hyperandrogenemic polycystic ovary syndrome (PCOS h-Ins) patient...

Hyperinsulinemic hyperandrogenism with anovulation, the so-called polycystic ovary syndrome (PCOS), is the most frequent endocrine disorder of young women. One of the stigmata of PCOS is a deficit of lean mass and an excess of fat, in particular, abdominal fat, even in the absence of obesity. Adiponectin and IL-6 are among the adipocytokines that have recently been related to abdominal fat exce...

background: in some disorders such as diabetes mellitus patients can display depressive symptoms. metformin is among the first-line treatments for management of the type 2 diabetes mellitus which may have some anti-depressant effect. objective: current investigation was performed to examine the anti-depressant effects of metformin and the involvement of nitric oxide (no) in this way, in an expe...

objective(s): diabetes mellitus is a public health problem and one of the five leading causes of death globally. in the present study, the effect of metformin with natural honey was investigated on glycemia in the streptozotocin-induced diabetic rats. materials and methods: thirty wistar male rats were randomly divided into six groups including c: non ­diabetic rats received distilled water, ch...

Context Hyperinsulinemia is often observed in obese people, owing to their insulin resistance accompanied by visceral fat accumulation, but the frequency of hyperinsulinemia in nonobese people is not well known. Mutations in the insulin receptor gene are known to cause insulin resistance and hyperinsulinemia in type A insulin resistance syndrome, Rabson-Mendenhall syndrome, and Donohue syndrome...