Introduction and Aim: In this study, a new sensitive rapid HPLC method was developed to determine Metformin hydrochloride Evogliptin tartrate in pharmaceutical dosage forms. Materials Methods: Chromatographic separation of achieved on Waters Alliance-e2695 by using XTerra RP-18 150X4.6 mm, 3.5µ column, the mobile phase containing Acetonitrile: KH2PO4: Methanol ratio 50:40:10% v/v. Results: The ...

CONTEXT Most antidiabetic agents target only 1 of several underlying causes of diabetes. The complementary actions of the antidiabetic agents metformin hydrochloride and rosiglitazone maleate may maintain optimal glycemic control in patients with type 2 diabetes; therefore, their combined use may be indicated for patients whose diabetes is poorly controlled by metformin alone. OBJECTIVE To ev...

Mucoadhesive polymer-coated pellets containing metformin hydrochloride were prepared by the powder-layering technique using a centrifugal fluidizing (CF)-granulator. Four high-viscosity polymers were applied to make the pellets: 1) hydroxymethylcellulose (HPMC), 2) sodium alginate (Na-Alg), 3) HPMC/Carbopol, and 4) sodium carboxylmethylcellulose (Na-CMC). The physical crushing test, mucoadhesiv...

A simple and stability indicating liquid chromatographic method was developed for the determination of purity of metformin hydrochloride drug substance, drug product in bulk samples and pharmaceutical dosage form in the presence of its impurities and degradation product. The mobile phase used consisted of Buffer: acetonitrile (90:10 %v/v) with pH 3.6 (adjusted with 0.006M phosphoric acid) and f...

Type 2 diabetes mellitus (T2DM) and its complications must be managed by using a comprehensive, or global, approach to treatment. The author describes the case of a white man, aged 51 years, with T2DM that was diagnosed 3 years earlier. The patient was obese and had a history of chronic low back pain. He also had diagnosed hypertension, decreased vibratory sensation in the feet, an S4 atrial ga...

sepsis as the host responsive syndrome is one of the main concerning issues and costly disease on intensive care unit (icu) in the 21st century. epidemiological studies have showed that mortality rates of sepsis in icu and hospitals among 37 countries were 39.2% and 49.6% respectively [1].  complicated nature of sepsis is still not well understood and this makes it hard to treat and manage. acc...

Ion-associate complexes of metformin hydrochloride drug employed in control of blood sugar level with ( manganese(II), zinc(II) and cadmium(II)) thiocyanates and ammonium reineckate are precipitated. The solubility of the solid complexes at the recommended optimum conditions of pH and ionic strength values have been studied. Saturated solutions of each ion associate at different temperatures un...