t Renal cell carcinoma is one of the highly aggressive tumors and notorious for late presentations. It is associated with high morbidity and mortality. Renal cell carcinoma is known for rare metastatic sites. In clinical practice, it is often important not to anchor to a particular diagnosis but rather revisit and revaluate entire history and clinical examination. We describe a case of metastat...

A bout 7 cases of esophageal carcinoma per 100 000 men are diagnosed in Taiwan, with variable metastatic tendency to other parts of the body. Esophageal carcinoma frequently metastasizes to the lungs and liver, although the metastatic deposits to the bone are infrequent and metastatic disease in the skull is extremely rare. We encountered a patient with a metastasis of esophageal carcinoma over...

Metastatic carcinomas involving the lung are a common specimen encountered in surgical pathology. These metastases may have different morphologic, and architectural patterns and may mimic primary pulmonary adenocarcinoma, especially the intra-alveolar (lepidic) pattern of spread which may simulate a primary pulmonary bronchioloalveolar carcinoma (adenocarcinoma in situ). We present the case of ...

CONTEXT Pancreatic involvement from metastatic renal cell carcinoma accounts for 0.25-3% of the cases. The distinction between primary pancreatic clear cell tumour and metastatic deposits from renal cell carcinoma may lead to diagnostic difficulties. Usually metastasis from renal cell carcinoma presents many years after the primary tumour has been resected. A typical metastatic lesion in pancre...

Malignant epithelial tumors presenting within the hernia sacs are rare, occurring in 0.14% of all surgically removed adult hernia sac cases [1]. Most reports document inguinal or umbilical hernia sac with metastatic adenocarcinoma from multiple organs [1-4]. To the best of our knowledge, no cases of ventral hernia sac with metastatic urothelial carcinoma have been previously reported. We herein...

Advances in surgical techniques and laparoscopic instruments have resulted in the development of laparoscopic pancreatic surgery. Total pancreaticoduodenectomy is performed for treating benign and borderline pancreatic disease involving the whole pancreas. Here, we report a case of metastatic renal cell carcinoma in the pancreas, treated by laparoscopic pylorus-preserving total pancreaticoduode...

Abstract Background Metastatic involvement of the breast is relatively rare and has an incidence 0.5–3%. Lesions that metastasize to may produce changes look similar those primary cancer on mammography, but they are more likely be multiple frequently bilateral. Case presentation A 38-year-old female complaining progressive proptosis with bilateral palpable lumps. She was referred imaging unit e...

Distinguishing primary ovarian carcinoma from metastatic carcinoma to the ovary is often difficult by histologic examination alone. Recently an immunohistochemical marker CDX-2 was found to be of considerable diagnostic value in establishing the gastrointestinal origin of metastatic tumors. The aim of this study was to determine whether CDX-2 can distinguish between these malignancies. Paraffin...

Systemic therapy for first-line metastatic renal cell carcinoma has evolved toward immune checkpoint blockade combinations incorporating a PD-1/L1 inhibitor along with CTLA-4 inhibition or VEGF-targeted therapy. The new treatment paradigm that integrates immunotherapy treatment-naïve advanced creates therapeutic challenge clinicians including the optimal way to integrate multidisciplinary care ...