نتایج جستجو برای: metabolic profile

تعداد نتایج: 428914  

Journal: :Archives of disease in childhood 1980
N K Griffin A Spanos P A Jenkins R C Turner G Werther J D Baum

15 metabolic profiles were performed on 10 diabetic children who were on once-daily injections of insulin. Blood and urine glucose concentrations were high throughout much of the day and night, and were associated with abnormal levels of blood ketones, lactate, and pyruvate. The plasma free-insulin profiles gave a characteristic pattern for each type of insulin. The investigation gives valuable...

2014
Ana C. Sousa João P. Vilas-Boas Ricardo J. Fernandes

A bioenergetical analysis of swimming at intensities near competitive distances is inexistent. It was aimed to compare the transient VO2 kinetics responses and metabolic contributions whilst swimming at different velocities around VO2max. 12 trained male swimmers performed (i) an incremental protocol to determine the velocity at VO2max (vVO2max) and (ii) three square wave exercises from rest to...

Journal: :Hypertension 2012
George C Roush Achuta K Guddati Theodore R Holford

Potency of Office Blood Pressure From Hydrochlorothiazide and Chlorthalidone Fails to Explain Cardiovascular Events To the Editor: Peterzan et al provide a meta-analysis that examines the doseresponse relationships on blood pressure for thiazide-like diuretics and find that chlorthalidone is 3 times more potent than hydrochlorothiazide (HCTZ) in reducing office systolic blood pressure. Their pr...

2014
Y Rojas S Naz JL Izquierdo N Nin A Ferruelo P García-Hierro D Molina-Arana R Herrero L Martínez-Caro A García MA de la Cal JM Ruiz-Cabello C Barbas JA Lorente

Introduction Acute lung injury induced by mechanical ventilation [ventilator-induced lung injury (VILI)]is characterized by a particular metabolic profile in the lung and in the systemic compartment [1]. Also, VILI has been associated with an increase in intestinal permeability [2]. We hypothesized that selective decontamination of the digestive tract (SDD) can modulate the metabolic profile as...

2012
Zhonghao Yu Guangju Zhai Paula Singmann Ying He Tao Xu Cornelia Prehn Werner Römisch-Margl Eva Lattka Christian Gieger Nicole Soranzo Joachim Heinrich Marie Standl Elisabeth Thiering Kirstin Mittelstraß Heinz-Erich Wichmann Annette Peters Karsten Suhre Yixue Li Jerzy Adamski Tim D Spector Thomas Illig Rui Wang-Sattler

Understanding the complexity of aging is of utmost importance. This can now be addressed by the novel and powerful approach of metabolomics. However, to date, only a few metabolic studies based on large samples are available. Here, we provide novel and specific information on age-related metabolite concentration changes in human homeostasis. We report results from two population-based studies: ...

2017
Elehazara Rubio-Martín Eva García-Escobar Maria-Soledad Ruiz de Adana Fuensanta Lima-Rubio Laura Peláez Angel-María Caracuel Francisco-Javier Bermúdez-Silva Federico Soriguer Gemma Rojo-Martínez Gabriel Olveira

The satiating effects of cow dairy have been thoroughly investigated; however, the effects of goat dairy on appetite have not been reported so far. Our study investigates the satiating effect of two breakfasts based on goat or cow dairy and their association with appetite related hormones and metabolic profile. Healthy adults consumed two breakfasts based on goat (G-Breakfast) or cow (C-Breakfa...

2010
Valter Tucci Glenda Lassi Patrick M. Nolan

The mouse has an extensive capacity to modulate timed responses and arm movements according to different environmental conditions and different genetic background may affect this ability. Recently, we have characterized a number of quantitative and qualitative meaningful endophenotypes related to mouse timing mechanisms and different motor actions. We have further investigated timing and motor ...

2010
Jie Mi Mercedes Nancy Munkonda Ming Li Mei-Xian Zhang Xiao-Yuan Zhao Ponce Cedric Wamba Fouejeu Katherine Cianflone

Objective. To evaluate leptin and adiponectin as biomarkers of metabolic syndrome (MS) risk factors even in nonobese children/adolescents. Methods. Serum leptin, adiponectin, leptin:adiponectin ratio, lipids, glucose, and insulin concentrations as well as body size parameters and pubertal development were evaluated in a large population of Chinese children/adolescents (n = 3505, 6-18 years, 172...

Journal: :Analytical chemistry 2007
Leon M Smith Anthony D Maher Olivier Cloarec Mattias Rantalainen Huiru Tang Paul Elliott Jeremiah Stamler John C Lindon Elaine Holmes Jeremy K Nicholson

Although NMR spectroscopic techniques coupled with multivariate statistics can yield much useful information for classifying biological samples based on metabolic profiles, biomarker identification remains a time-consuming and complex procedure involving separation methods, two-dimensional NMR, and other spectroscopic tools. We present a new approach to aid complex biomixture analysis that comb...

Journal: :Trends in biochemical sciences 1999
C V Dang G L Semenza

Over seven decades ago, classical biochemical studies showed that tumors have altered metabolic profiles and display high rates of glucose uptake and glycolysis. Although these metabolic changes are not the fundamental defects that cause cancer, they might confer a common advantage on many different types of cancers, which allows the cells to survive and invade. Recent molecular studies have re...

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