A link between insulin metabolism and colorectal cancer has been hypothesized, supported by a series of potential physiological mechanisms, and confirmed by a number of reports in experimental animals. However, the evidence in humans is limited and mostly indirect. The aim of the present report is to analyze whether individuals with a cluster of metabolic abnormalities associated with abnormali...

BACKGROUND To test the hypothesis that preserved muscle mass is protective against obesity-associated insulin resistance and metabolic abnormalities, we analyzed the relationship of lean body mass and computed tomography-assessed sectional areas of specific skeletal muscles with insulin resistance and metabolic abnormalities in a healthy cohort. METHODS A total of 195 subjects without diabete...

AIMS The present study aimed to investigate relationships among abdominal obesity, metabolic abnormalities, and the prevalence of chronic kidney disease (CKD) in relatively lean Japanese men and women. PARTICIPANTS AND METHODS The participants included 8133 men and 15 934 women between 40 and 75 years of age recruited from the government health check-up center in Kanazawa City, Japan. The pre...

Metabolic disturbances and fat redistribution have been characterized in HIV-infected patients receiving combination antiretroviral therapy according to drug exposure and patterns of fat redistribution. In contrast, we investigated metabolic abnormalities in a well-characterized cohort of HIV-infected patients with clinical lipodystrophy in comparison with an established population of healthy c...

Acid-base disorders are common clinical problems resulting from a wide variety of pathophysiological conditions, including newly recognised acquired and genetic causes. The history and physical examination and measurement of blood and urinary indices allow identification of the underlying cause of these disorders in most cases. Treatment directed at correction of electrolyte abnormalities and t...