Pheochromocytoma and paraganglioma are catecholamine-producing tumors that arise from the adrenal glands or paraganglia. These rarely occur in chest, especially anterior mediastinum. Here, we describe a rare case of mediastinum, report on key points surgery perioperative management. An 80-year-old woman was admitted to our hospital for fatigue hypertension. A 123I-meta-iodobenzylguanidine scint...

Prognosis of high-risk neuroblastoma (HRNB) remains poor despite multimodal therapies. Better prediction survival could help to refine patient stratification and better tailor treatments. We established a mechanistic model metastasis in HRNB relying on two processes: growth dissemination patient-specific parameters: the rate μ minimal visible lesion size S vis . This was calibrated using diagno...

As observed by other authors, normal adrenal medullary tissue frequently gives an apparently positive meta-iodobenzylguanidine (MIBG) scan in cases studied using 123I-MIBG and less frequently 131I-MIBG. The aim of this study was to assess the usefulness of a scoring system, based on different uptakes of the radiopharmaceutical, to improve the accuracy of 123I-MIBG scintigraphy in patients with ...

Ganglioneuroblastoma and neuroblastoma are malignant catecholamine-secreting tumors arising from neural crest tissue. Thirty-eight cases of functional retroperitoneal extra-adrenal neuroblastoma and ganglioneuroblastoma in adults are reported in English literature. These tumors behave more aggressively in adults compared to children and have very poor prognosis. We report four adults who presen...

(123)I-meta-iodobenzylguanidine (MIBG) has become widely applied in Japan since its introduction to clinical cardiology and neurology practice in the 1990s. Neurological studies found decreased cardiac uptake of (123)I-MIBG in Lewy-body diseases including Parkinson's disease and dementia with Lewy bodies. Thus, cardiac MIBG uptake is now considered a biomarker of Lewy body diseases. Although sc...

PURPOSE Both [(131)I]meta-iodobenzylguanidine ([(131)I]MIBG) and the topoisomerase I inhibitor topotecan are effective as single-agent treatments of neuroblastoma. The aim of this study was to investigate the efficacy of [(131)I]MIBG in combination with topotecan in vitro and in vivo. EXPERIMENTAL DESIGN The cell lines used were SK-N-BE(2c) (human neuroblastoma) and UVW/NAT (glioma cell line ...

PURPOSE Myocardial sympathetic imaging with 123I-meta-iodobenzylguanidine (123I-mIBG) has gained clinical momentum. Although the need for standardization of 123I-mIBG myocardial uptake has been recognized, the availability of practical clinical standardization approaches is limited. The need for standardization includes the heart-to-mediastinum ratio (HMR) and washout rate with planar imaging, ...