• Rd is endowed with the standard inner product (·, ·) and Euclidean norm ‖ · ‖. • Md×d(R) denotes the space of n× n real matrices. • When Rd = E ⊕ F is a splitting of Rd into complementary subspaces, we let πE//F denote the projection onto E, parallel to F ; that is, the range of πE//F is E, πE//F ◦ πE//F = πE//F , and kerπE//F = F . • For a subspace E ⊂ Rd, let πE denote the orthogonal projec...

Feeding metabolism and the activation of myogenic progenitor cells were investigated in the fast myotomal muscle of the sub-Antarctic fish Hapagifer bispinis acclimatized to either simulated summer (10 degrees C; 18 h:6 h light:dark) or simulated winter (5 degrees C; 6 h:18 h light:dark) conditions. Ingestion of a single meal equivalent to 10% and 15% of body mass in simulated winter and summer...

BACKGROUND Meningiomas show high recurrence rates even after curative tumor removal. The invasiveness of meningiomas may contribute to their high recurrence rates. Recently, c-MET and hepatocyte growth factor (HGF) have been reported to be involved in cancer invasion. METHODS We examined the immunohistochemical expression of c-MET and HGF in 100 cases of patients with meningiomas who have und...

The mammary gland is a renewing tissue in which morphogenetic processes and differentiation occur cyclically during the menstrual cycle, pregnancy and lactation. These events have been shown to be dependent upon epithelial-mesenchymal interactions. Studies of the effects of individual factors, their cellular source and their target cell populations in the different developmental stages of the m...

Monoclonal antibodies can be seen as valuable tools for many aspects of basic as well as applied sciences. In the case of MET/HGFR, they allowed the identification of truncated isoforms of the receptor, as well as the dissection of different epitopes, establishing structure-function relationships. Antibodies directed against MET extracellular domain were found to be full or partial receptor ago...

c-Met, a type of receptor tyrosine kinase, may be significantly associated with the progression of hepatocellular carcinoma (HCC). In addition, des-γ-carboxyprothrombin (DCP) has been found to interact with c-Met and activate HCC cell growth. Therefore, the functional inhibition of c-Met expressed on HCC cells should arrest HCC cell growth. The present study found that the c-Met inhibitor SU112...

Over the past decades, systemic treatment including targeted therapies and immunotherapies has changed landscape of NSCLC.1Herbst R.S. Morgensztern D. Boshoff C. The biology management non-small cell lung cancer.Nature. 2018; 553: 446-454Crossref PubMed Scopus (1129) Google Scholar Currently, tests for specific molecular alterations that predict response to (e.g., EGFR mutation, ALK rearrangeme...

Objective(s): Breast cancer remains a global challenge, and further chemopreventive therapies are still immediately required. Emerging evidence has revealed the potent anti-cancer effects of biguanides, Metformin (MET) and phenformin (PHE). Thus, to explore an efficient chemopreventive strategy for breast cancer, the antiproliferative effects of the combination of MET and PHE against breast can...