BACKGROUND Meropenem plays a significant role in the current antimicrobial treatment of serious infections. Recently, generic meropenems have become widely available in Thailand. OBJECTIVE Compare the effectiveness and safety ofa generic meropenem (Mapenem) with the original meropenem (Meronem) in clinical practice. MATERIAL AND METHOD A retrospective cohort study was conducted in hospitali...

INTRODUCTION Clinicians' skepticism, fueled by evidence of inferiority of some multisource generic antimicrobial products, results in the underutilization of more cost-effective generics, especially in critically ill patients. The aim of this observational study was to demonstrate equivalence between the generic or comparator brand of meropenem (Mercide®) and the leading innovator brand (Merone...

background :    acinetobacter baumannii has become one of the most important causes of nosocomial infections in recent years. the organism seems to be resistant to most classes of antibiotics. carbapenems are considered the most effective drugs for treatment of these infections. however, increasing emergence of carbapenem resistant a. baumannii has become a major healthcare problem.   methods :...

UNLABELLED In the study we tested drug sensitivity to 3 carbapenems (doripenem, imipenem and meropenem) of Gram-negative clinical isolates from Southern Poland. MATERIAL AND METHODS 89 strains were examined: 42 from Pseudomonas genus, 16 Acinetobacter baumannii strains and 31 Enterobacteriaceae strains. Etests were used according to the producers instructions, MIC values were interpreted usin...

Carbapenem resistance presents severe threat to the treatment of multidrug resistant Pseudomonas aeruginosa infections. The study was undertaken to investigate the role of efflux pumps in conferring meropenem resistance and effect of single dose exposure of meropenem on transcription level of mexA gene in clinical isolates of P. aeruginosa from a tertiary referral hospital of India. Further, in...

The nosocomial spread of carbapenem-resistant Enterobacteriaceae (CRE) is a serious concern for health care facilities (1, 2), and environmental sources are being increasingly implicated (3– 6). Carbapenems can be used to select for CRE in environmental testing, but detection may be impacted when organisms are present in low numbers. Bacterial tolerance to carbapenems can increase as inoculum s...

Pharmacokinetic and pharmacodynamic profiles of antibiotics are important in determining effective dosing regimens. Although minimum inhibitory concentration (MIC) data reflect microbial susceptibility to an antibiotic, they do not provide dosing information. The integration of pharmacokinetic and microbiological data, however, can be used to design rational dosing strategies. Meropenem is a br...

All drugs have the potential cause to side effects and anaphylaxis.The bioavailability of the drugs is different in newborns. Therefore has the tolerability and efficacy of the medicationsin the newborn period more importance. Meropenem is a broad-spectrum antibiotic used to treat a wide variety of infections. We describe here a neonate who developed anaphylactic shock after use of intravenous ...

OBJECTIVE To investigate the in vitro effects of the antibacterial drugs, meropenem trihydrate, piperacillin sodium, and cefoperazone sodium, on the activity of human serum paraoxonase (hPON1). METHODS hPON1 was purified from human serum using simple chromatographic methods, including DEAE-Sephadex anion exchange and Sephadex G-200 gel filtration chromatography. RESULTS The three antibacter...

Necrotizing enterocolitis (NEC) continues to be a major cause of neonatal morbidity and mortality. We describe the added value of therapeutic drug monitoring by presenting the case of a preterm infant with severe NEC treated with meropenem. Dosing strategy will achieve adequate patient outcome when treating pathogens with elevated MIC. As safe as meropenem is, there are not enough data for 40 m...