nanocrystalline sio2–hclo4, as a newly reported catalyst, has been used as an efficient and reusable catalyst for the synthesis of pyrimidine derivatives. the procedure can be successfully applied to the efficient synthesis of mono substituted pyrimidine derivatives, using triethyl orthoformate, ammonium acetate, methyl ketone derivatives. in practice, this method is a combination of a satisfac...

Human cytomegalovirus (HCMV) induces numerous changes to the host metabolic network that are critical for high-titer viral replication. We find that HCMV infection substantially induces de novo pyrimidine biosynthetic flux. This activation is important for HCMV replication because inhibition of pyrimidine biosynthetic enzymes substantially decreases the production of infectious virus, which can...

In an endeavor to find a novel series of antihyperglycemic agents, new benzimidazole and pyrimidine derivatives were successfully synthesized efficiently in high yield with high purity, starting from amino acids in the presence of phosphorus oxychloride (POCl3). The synthesized compounds were identified by 1H-NMR, 13C-NMR, FT-IR spectroscopic techniques and elemental analysis. All products were...

The title compound, [Cu(C(5)H(3)N(2)O(2))(2)], was prepared in a water-ethanol solution containing 2-cyano-pyrimidine, malonic acid and copper(II) nitrate trihydrate. The Cu(II) ion, located on an inversion center, is chelated by two pyrimidine-2-carboxyl-ate anions in a CuO(2)N(2) square-planar geometry. The uncoordinated carboxyl-ate O atom and pyrimidine N atoms are linked to adjacent pyrimi...

Purine and pyrimidine nucleotides play critical roles in DNA and RNA synthesis as well as in membrane lipid biosynthesis and protein glycosylation. They are necessary for the development and survival of mature T lymphocytes. Activation of T lymphocytes is associated with an increase of purine and pyrimidine pools. However, the question of how purine vs pyrimidine nucleotides regulate proliferat...

Two subspecies of mainland leopard cats ( Prionailurus bengalensis ), Iriomote iriomotensis and Tsushima euptilurus are small, endangered felids that endemic to the Japanese islands, Iriomote-jima Tsushima, respectively. Both have an estimated population size only about 100 individuals each. Therefore, it is crucial expand our understanding these successfully conserve them. While their morpholo...

General synthetic routes to 4-methyl-5-arylpyrimidines and 5-arylpyrimidines are described. 4-Benzylpyrimidine, 4-methyl-5-phenylpyrimidine, 4-(4-methoxybenzyl)pyrimidine, and 4-methyl-5-(4-methoxyphenyl)pyrimidine have been positively identified as route-specific by-products in the Leuckardt preparations of amphetamine and 4-methoxyamphetamine. Using headspace solid phase microextraction (SPME...