The flowers of the primitive angiosperm plants were radially symmetrical (actinomorphic). Flowers with bilateral symmetry (zygomorphic) evolved in several clades independently as an adaptation to specialized methods of pollination and played an important role in the diversification of flowering plants. In the model species Antirrhinum majus (snapdragon), the related genes CYCLOIDEA (CYC) and DI...

Drosophila Clock (dClk) is rhythmically expressed, with peaks in mRNA and protein (dCLK) abundance early in the morning. dClk mRNA cycling is shown here to be regulated by PERIOD-TIMELESS (PER-TIM)-mediated release of dCLK- and CYCLE (CYC)-dependent repression. Lack of both PER-TIM derepression and dCLK-CYC repression results in high levels of dClk mRNA, which implies that a separate dClk activ...

The Drosophila circadian oscillator consists of interlocked period (per)/timeless (tim) and Clock (Clk) transcriptional/translational feedback loops. Within these feedback loops, CLK and CYCLE (CYC) activate per and tim transcription at the same time as they repress Clk transcription, thus controlling the opposite cycling phases of these transcripts. CLK-CYC directly bind E box elements to acti...

Let G be a transitive permutation group acting on a finite set Ω. A cycle c is involved in a permutation g if and only if gc−1 fixes all points of Supp(c). We define a function Cyc(G) which takes the permutation group G to the group generated by the cycles involved in its elements. Let Cyc1(G) = Cyc(G) and Cyci+1(G) = Cyc(Cyci(G))). It is known that Cyc3(G) = Cyc4(G) for all such groups. We inv...

Since the introduction of combined immunosuppressive therapy consisting of oral cyclophosphamide (CYC) and glucocorticosteroids (GC) in the 1970s, the outcome of antineutrophil cystoplasmic antibodies (ANCA)-associated vasculitides has improved dramatically over the last decades. However, the long-term follow-up of patients treated with CYC plus GC has revealed a high treatment-related morbidit...

Mitochondrial-mediated oxidative stress and apoptosis play a crucial role in neurodegenerative disease and aging. Both mitochondrial permeability transition (PT) and swelling of mitochondria have been involved in neurodegeneration. Indeed, knockout mice for cyclophilin-D (Cyc-D), a key regulatory component of the PT pore (PTP) that triggers mitochondrial swelling, resulted to be protected in pr...

This article is also accessible online at: http://BioMedNet.com/karger Dear Sir, We have published a study documenting the effect of inhaled cyclosporin A (Cyc-A) on the rat airway inflammation in this issue [1]. Our approach to assess the effect of pure Cyc-A was not rigorous since we used a commercial Cyc-A ampoule (50 mg cyclosporin A, 278 mg ethanol and 650 mg castor oil in a 1-ml intraveno...

The characteristics of 58 strains of Lactobacillus spp. isolated from kefir were studied. These strains were tested for adherence to human enterocyte-like Caco-2 cells, resistance to acidic pH and bile acid, antimicrobial activities against enteropathogenic bacteria and inhibition of Salmonella typhimurium attachment to Caco-2 cells. The best probiotic properties were observed in L. acidophilus...

This reflection writing was co-written by seven young people and three Master of Arts Child Youth Care (MA CYC) students from Ryerson University. Our centres around a Canadian youth-led initiative called First, developed as MA CYC placement due to the lack opportunities available during pandemic. First focused on creating safe interactive spaces in cyberspace for Through this reflection, we hop...

INTRODUCTION Infectious diseases are a significant cause of morbidity and mortality in patients with connective tissue diseases. Corticosteroids and immunosuppressive drugs, such as cyclophosphamide (CYC), increases the risk of infections. The objective of this study was to estimate the incidence rates of severe infections in patients who received treatment with CYC. PATIENTS AND METHODS The ...