Both atenolol and propranolol by mouth reduce ocular tension in normal and glaucomatous eyes (Phillips, Howitt, and Rowlands, i967; Elliot, Cullen, and Phillips, 1975; Wettrell and Pandolfi, 1975). These drugs are f-adrenergic blockers but propranolol affects both P1 and 32 receptors (as well as having a 'membrane' effect), while atenolol is a more specific 31 receptor antagonist and lacks the ...

Prostate-specific membrane antigen (PSMA) is a protein up-regulated in the vast majority of prostate cancers. Antibodies to PSMA have proved highly specific for prostate cancer cells, and the therapeutic potential of such antibodies is currently being assessed in clinical trials. We have previously shown that PSMA at the cell surface of polarized epithelial cells is predominantly expressed at t...

We investigated the influence of pinoline (0.01-1.5 mM) on microsomal membrane fluidity before and after rigidity was induced by oxidative stress. In addition, we tested the effect of pinoline in the presence of 1 mM melatonin. The fluidity in rat hepatic microsomes was monitored using fluorescence spectroscopy and it was compared to the inhibition of malonaldehyde (MDA) plus 4-hydroxyalkenals ...

The flexibilities of extracellular loops determine ligand binding and activation of membrane receptors. Arising from fluctuations in inter- and intraproteinaceous interactions, flexibility manifests in thermal motion. Here we demonstrate that quantitative flexibility values can be extracted from directly imaging the thermal motion of membrane protein moieties using high-speed atomic force micro...

Solid electrolytes used in all-solid-state batteries electronically separate the positive and negative electrodes battery only allow carrier ions to pass through. KTiOPO 4 (KTP), a potassium ion-conducting solid electrolyte, was first applied as inner contact layer of an ion-selective electrode (ISE) stabilize membrane potential. Application KTP improved long-term potential stability ISE by sta...

Photosystem I (PSI) achieves photo-induced charge separation with outstanding internal quantum efficiency and has been used to improve the performance of various photoelectrochemical systems. Herein, we describe a fast and versatile technique to assemble composite films containing PSI and a chosen intrinsically conductive polymer (ICP). A mixture of PSI and a Friedel-Crafts catalyst (FeCl3) is ...

Enzymes in living cells are highly dynamic but at the same time regularly confined for achieving efficient metabolism. Inspired by this phenomenon, we have prepared a novel biocatalytic membrane with high enzyme activity and stability tuning confinement strength of to enzyme, which was achieved via modifying support layer polymeric nanofiltration (NF) reversely filtrating enzyme. A mussel-inspi...

The main purpose of this paper is to revisit the internal/simultaneous/robust stabilization problems without assuming the existence of doubly coprime factorizations for the transfer matrices. Indeed, it has been recently shown in the literature that an internally stabilizable does not generally admit doubly coprime factorizations. Firstly, we give new necessary and sufficient conditions for int...

The ternary complex of spectrin, actin, and 4.1R (human erythrocyte protein 4.1) defines the nodes of the erythrocyte membrane skeletal network and is inseparable from membrane stability under mechanical stress. These junctions also contain tropomyosin (TM) and the other actin-binding proteins, adducin, protein 4.9, tropomodulin, and a small proportion of capZ, the functions of which are poorly...