Trypanosoma brucei, the parasite that causes human African trypanosomiasis, is auxotrophic for purines and has specialist nucleoside transporters to import these metabolites. In particular, the P2 aminopurine transporter can also selectively accumulate melamine derivatives. In this Letter, we report the coupling of the melamine moiety to 2-hydroxy APA, a potent ornithine decarboxylase inhibitor...

Single-stranded DNA-melamine hybrid molecular building blocks were synthesized using a phosphoramidation cross-coupling reaction with a zero linker approach. The self-assembly of the DNA-organic hybrid molecules was achieved by DNA hybridization. Following self-assembly, two distinct types of nanostructures in the form of linear chains and network arrays were observed. The morphology of the sel...

Three formaldehyde-based resins were prepared: urea-formaldehyde (UF) resin without melamine modifier (named UF0 resin) and melamineurea-formaldehyde (MUF) resins with melamine modifier added at two different synthesis stages (named MUF1 resin and MUF2 resin). The effects of the melamine addition stage on the performance and curing behavior of MUF resin were studied. Three-ply plywood bonded by...

We demonstrate in this joint experimental and theoretical study how one can alter electron transport behavior of a single melamine molecule adsorbed on a Cu (100) surface by performing a sequence of elegantly devised and well-controlled single molecular chemical processes. It is found that with a dehydrogenation reaction, the melamine molecule becomes firmly bonded onto the Cu surface and acts ...

Graphite like C3N4 (g-C3N4) was synthesized facilely via the low temperature thermal condensation of melamine between 300-650°C. The results showed that the products maintained as melamine when the temperature is below 300°C. With the increase of temperature, the products were transformed into carbon nitride and amorphous g-C3N4 successively. The morphology of products was changed from spherica...

Commercially used industrial baking enamels consist of alkyd or polyester resin with melamine formaldehyde. These resins are mainly derived from fossil resources. Considering growing environmental legislation regarding use of petroleum based raw materials, utilization of renewable resources to synthesize various chemistries can be the only obvious option as far as academia and industries are co...

Human African trypanosomiasis (HAT), caused by the protozoan parasite Trypanosoma brucei spp., is a major health problem in sub-Saharan Africa. New drugs are urgently required for the disease. Selective uptake of toxic compounds into trypanosomes has been achieved by exploiting plasma membrane transporters. For example, the P2 aminopurine transporter, along with other transporters, selectively ...

Through screening, diagnosing, and treating childhood urinary stones induced by melamine-tainted formula, Chinese doctors obtained more experience with the clinical as well as the imaging features of the stones, although there still are many questions regarding melamine-associated stones. By reviewing the earlier reports on animals along with our recent experiences with humans, we concluded tha...

The CO2 capturing and sequestration are of importance in environmental science. Understanding of the CO2-interactions with various functional molecules including multi-N-containing superbases and heteroaromatic ring systems is essential for designing novel materials to effectively capture the CO2 gas. These interactions are investigated using density functional theory (DFT) with dispersion corr...