The management of thyroid cancer has been facilitated by the recent publication of the Guidelines for the management of thyroid cancer in adults under the auspices of the British Thyroid Association and the Royal College of Physicians. This is a consensus document that has been developed by a number of key investigators in the field. The central tenet of the guidelines is that thyroid cancer is...

INTRODUCTION Medullary thyroid cancer is a rare carcinoma. Surgery is the only curative treatment and since cervical lymphnodes metastases are frequent and can occur at an early stage, a standardized central lymphnode dissection is associated to total thyroidectomy. However, the extent of lymphadenectomy to the lateral neck lynphnodes remains debated. To reduce the extent of lymphnode excision,...

To gain an understanding of the molecular pathogenesis of thyroid cancer, we used DNA microarray to study the expression profiles of 10 different human thyroid carcinoma cell lines. These included papillary lines BHP 2-7, BHP 7-13, BHP 10-3, BHP 18-21, NPA 87, and TPC1; anaplastic lines ARO 81-1 and DRO 90-1; follicular line WRO 82-1; and medullary line HRO 85-1. Among the genes with increased ...

UNLABELLED INTRODUCTION Papillary thyroid microcarcinoma has been demonstrated to present in association with medullary thyroid carcinoma, however, medullary thyroid carcinoma and papillary thyroid carcinoma represent rare entities. In recent years this rarity has been increasingly observed. The pathogenesis is still controversial. Genetic analysis of RET proto-oncogenes in cases of simultan...

This paper reviews the state-of-the-art on the management of thyroid cancer in humans, including the following thyroid carcinomas: papillary, follicular, poorly differentiated (insular), undifferentiated (anaplastic), and medullary (sporadic and inherited forms). Also metastatic (secondary) neoplasms of the thyroid gland have been approached. The rules of treatment (surgical, with use of I and ...

Medullary Thyroid Carcinoma (MTC) is a rare thyroid tumor that arises from neural crest-derived Calcitonin producing Para follicular C cells and accounts for approximately 4 % of thyroid malignancies. This neuroendocrine tumor typically is an aggressive cancer, with secretion of several neuro-humoral mediators. We report a case of 49 year old male patient who presented with episodes of chest di...

BACKGROUND The incidence of thyroid cancer (TC) is increasing although explanatory causes are lacking. A link between cancer and inflammation is well documented but unclear for autoimmune thyroid diseases and TC. We aimed to systematically review the association between Hashimoto's thyroiditis (HT) and papillary, follicular, medullary, anaplastic thyroid carcinoma, and thyroid lymphoma (TL). ...

BACKGROUND Surgical resection is the key to management of thyroid cancer, but determining the optimal surgical procedure for individual cases has been controversial. METHODS The author reviews several large data bases that allow examination of prognostic criteria for long-term outcomes. RESULTS Patients can be classified into good- or poor-risk groups that assist defining the optimal surgic...

UNLABELLED The aim of the present study was to present data on frequency of thyroid cancer in Mures County (Romania) and border counties, a goiter endemic area, and to analyze its histopathological characteristics, over a 20 years period (1990-2009). MATERIALS AND METHODS Demographic, clinical and pathological data were obtained from database registries. Histological subtypes of thyroid cance...

Medullary thyroid cancer accounts for less than 10% of all thyroid cancers. Aggressive metastatic forms of this disease however, are incurable and can cause significant symptoms including diarrhea and pain. Hereditary and some sporadic forms of the disease are characterized by a mutation of the proto-oncogene RET. This results in an abnormal growth factor receptor that, in turn, allows the mali...