BACKGROUND Renal artery stenosis (RAS) impacts the pathogenesis and control of heart failure (HF) and may further contribute to increased cardiovascular morbidity and mortality in HF patients. However, the long-term effects of renal artery revascularization on cardiovascular outcomes in HF patients are not well studied. METHODS The prevalence of HF and its effects on all-cause mortality were ...

during recent decades publishing articles in academic journals has become a worldwide urge for all members of academia. there is, however, a widespread belief according to which more value is given to the articles published in internationally-recognized, high standard journals. an issue raised in this regard is whether the articles published in highly prestigious journals are remarkably differe...

Background and objectives: Recurrent aphthous stomatitis (RAS) is a painful ulcerative lesion and its incidence is 20% in the society. Myrtus communis (myrtex) has been effective in the treatment of RAS. In this study, two different concentrations (2.5% versus 5%) of myrtex extract were evaluated to discover the most effective concentration for the treatment of RAS. Methods: In this randomized...

Background: Anti-EGFR therapies have been recommended for advanced colorectal cancer (CRC) with wild-type RAS and PIK3CA mutation. However, PIK3CA mutations are a poor prognostic marker and a negative predictor of response to anti-EGFR therapies in RAS wild-type CRC. Therefore, new and advanced treatment strategies are needed for personalized medical treatment of patients with wild-type RAS and...

INTRODUCTION Renovascular hypertension (RVH) is caused by renal ischaemia associated with haemodynamically significant renal artery stenosis (RAS). The choice of optimal treatment of atherosclerotic RAS is still controversial. Increase in the renal resistive index (RI) value after captopril administration is considered to indicate preserved renal autoregulation. The objective of the study was t...

      During recent decades publishing articles in academic journals has become a worldwide urge for all members of academia. There is, however, a widespread belief according to which more value is given to the articles published in internationally-recognized, high standard journals. An issue raised in this regard is whether the articles published in highly prestigious journals are remarkably d...

Arterial hypertension (AH) is a major cardiovascular risk factor and often coexists with insulin resistance. Insulin resistance impairs glucose homeostasis has been associated the development of new-onset type 2 diabetes mellitus (T2D). Overactivity renin-angiotensin system (RAS) mediated by angiotensin II adversely affects homeostasis. The blockade RAS use converting enzyme inhibitors (ACEi) o...

The prevalence of atherosclerotic renal artery stenosis (RAS) is more common than was previously thought, particularly in patients with known coronary, cerebrovascular, or peripheral vascular atherosclerosis. Clinical subsets in which RAS is more common include patients with uncontrolled hypertension, renal insufficiency, and/or sudden onset ("flash") pulmonary edema. Renal artery atheroscleros...