We propose a hybrid dynamical system approach to model the evolution of a pathogen that experiences different selective pressures according to a stochastic process. In every environment, the evolution of the pathogen is described by a version of the Fisher-Haldane-Wright equation while the switching between environments follows a Markov jump process. We investigate how the qualitative behavior ...

Optogenetic tools enable light-mediated control of cellular excitability and signaling in vivo. By manipulating biological processes, scientists can determine the roles played by these processes in intact biological systems, such as the brain. Such cellular-level control has greatly affected basic science. Here, we discuss how optogenetic tools might be translated into clinical impact through i...

One of the problems that we have found when teaching human physiology in a Spanish medical school is that the degree of understanding by the students of the integration between organs and systems is rather poor. We attempted to remedy this problem by using a case discussion method together with the Quantitative Circulatory Physiology (QCP) program. QCP is a Windows-based computer simulation pro...

background: the comprehension processes are often inferred or explored indirectly through the assessment of the performance of the students on certain tasks. comprehension is typically measured by the techniques in which the test-taker reads a short text and then selects the correct answers in multiple choice questions, true/false and yes/no tasks or matching activities. purpose: a new approach...

The availability of genome sequences from a multitude of organisms, which began about a decade ago, has had enormous impact throughout the biomedical sciences. These sequence data have changed the way research studies are carried out and have led to the explosive growth of computational biology as an approach to analyze biological processes and evolution. In medicine, the completion of the huma...

The goals of medical education are to provide students and graduate clinicians specific facts and information, to teach strategies for applying this knowledge appropriately to the situations that arise in medical practice, and to encourage development of skills necessary to acquire new knowledge over a lifetime of practice. Students must learn about physiological processes and must understand t...

the aim of this study was to show the interaction between the society, applicants and medical schools in terms of medical student selection. in this study, the trends to implement social factors in the selection process were highlighted. these social factors were explored through functionalism and conflict theories, each focusing on different categories of social factors. while functionalist th...

This paper describes our experiences in defining the processes associated with preparing and administrating chemotherapy and then using those process definitions as the basis for analyses aimed at finding and correcting defects. The work is a collaboration between medical professionals from a major regional cancer center and computer science researchers. The work uses the Little-JIL language to...