It is estimated that one third of patients with seizures have medically intractable epilepsy (MIE) – defined as failure of two antiepileptic medications given at appropriate doses1,2. Temporal lobe epilepsy (TLE) is the most common form of MIE. The most frequent pathologic substrate related to this condition is sclerosis and atrophy of the hippocampus – disease named mesial temporal sclerosis (...

BACKGROUND AND PURPOSE We objectively assessed surface structural changes of the hippocampus in mesial temporal sclerosis (MTS) and assessed the ability of large-deformation high-dimensional mapping (HDM-LD) to demonstrate hippocampal surface symmetry and predict group classification of MTS in right and left MTS groups compared with control subjects. METHODS Using eigenvector field analysis o...

The surgical treatment of epilepsy is the most efficacious therapeutic modality for patients with a medically refractory partial seizure disorder. Epilepsy surgery has been demonstrated to be both effective and well tolerated in individuals with medial temporal lobe epilepsy associated with mesial temporal sclerosis. The identification of an MRI pathological substrate may be useful in identifyi...

The anterior medial temporal lobe (TL), including the amygdala, has been implicated in olfactory processing, e.g., coding for intensity and valence, and seems also involved in memory. With this background, the present study evaluated whether anterior medial TL-resections in TL epilepsy affected intensity and valence ratings, as well as free and cued identification of odors. These aspects of odo...

Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene expression in the hippocampus. Epigenetic changes to DNA are attractive mechanisms to explain the sustained hyperexcitability of chronic epilepsy. Here, through methylation analysis of all annotated C-phosphate-G islands and promoter regions in the human genome, we report a pilot study of the methylation profile...

Objective Medial temporal lobe epilepsy (MTLE) is a drug-resistant focal that can be caused by broad spectrum of different inciting events, including tumors, febrile seizures, and viral infections. In human surgical resections as well in animal models, an involvement the adaptive immune system was observed. We here analyzed presence T cells various subgroups MTLE. aimed to answer question how m...

We evaluated the ability of preoperative radiologic imaging to detect hippocampal sclerosis in 31 patients who underwent surgery for intractable epilepsy. Hippocampal sclerosis is commonly associated with surgically treatable temporal lobe epilepsy. It is pathologically described as neuronal cell loss with associated gliosis in the hippocampus. While previous reports have correlated imaging res...

Surgery has proven quite effective in patients with pharmacoresistant temporal lobe epilepsies (TLE). Unilateral hippocampal sclerosis, in particular, is associated with positive seizure control following surgery. However, surgical relief from epileptic seizure activity may come at the expense of neuropsychological deficits. Thus, during the evaluation of patients being considered for epilepsy ...

Background: Patients suffering from non-lesional medial temporal lobe epilepsy can, based on the appearance of the hippocampus, be divided into 2 clinical sub-groups: TLE with mesial temporal sclerosis as defined by MRI (TLE-mts), and those with normal appearing MRI on visual inspection (TLE-no). Structural MRI studies have consistently demonstrated global volumetric changes in TLE-mts. Structu...