The dependence of PC(1) and ATP(1) dephosphorylation on the number of isometric twitches in the iodoacetate-nitrogen-poisoned muscle has been examined. There is no net dephosphorylation of adenosinetriphosphate. PC dephosphorylation varies linearly with the number of twitches and produces equivalent amounts of C(1) and P(1i).(1) Iodoacetate concentrations which block the enzyme, creatine phosph...

The utilization of creatine phosphate (CP) and adenosine triphosphate (ATP) was studied in the iodoacetate (IAA) and nitrogen (N(2))-treated cat papillary muscle. Under these conditions the net production of ATP does not occur, and the net utilization of ATP is reflected in a fall in CP concentration. The rate of energy utilization of the IAA-N(2)-treated cat papillary muscle resting without te...

If, contrary to conventional models of muscle, it is assumed that molecular forces equilibrate among rather than within molecular motors, an equation of state and an expression for energy output can be obtained for a near-equilibrium, coworking ensemble of molecular motors. These equations predict clear, testable relationships between motor structure, motor biochemistry, and ensemble motor func...

NoT MANY albuminous bodies have been as successfully examined for their microand macro-structure as hair and wool keratin. Chemical, optical and mechanical methods of measurement were used in this task. The latter, especially, figured in many publications of the last 30 years, so that the special term "Mechanochemistry" was coined for the mechanical methods of measurement, and it is surprising ...