Mechanical strain is a potent stimulus for growth and remodeling in cells. Although many pathways have been implicated in stretch-induced remodeling, the control structures by which signals from distinct mechano-sensors are integrated to modulate hypertrophy and gene expression in cardiomyocytes remain unclear. Here, we constructed and validated a predictive computational model of the cardiac m...

Based on the concepts of theory interaction and research in course researching process studying composite polymer materials using method modeling - mechano-electric contact interaction. The proposed formula for determining coefficient friction pulp (raw cotton).

A Hadamard instability analysis of the partial differential equations governing a coupled thermo-mechano-chemical system predicts instability of the spinoidal decomposition type as well as instability of the "negative creep" type.

Chiral effects in 2D Cosserat continuum model may arise from coupling between stretching deformations and the micro-rotation for hemitropic materials. An orthotropic chiral is introduced to account this type of coupling. The expected are verified through an experimental effort using a specimen with granular motif. A micro-mechano-morphology considered that leads macroscopic response. resultant ...

Scaffold design remains a main challenge in tissue engineering due to the large number of requirements that need to be met in order to create functional tissues in vivo. Computer simulations of tissue differentiation within scaffolds could serve as a powerful tool in elucidating the design requirements for scaffolds in tissue engineering. In this study, a lattice-based model of a 3D porous scaf...

Development of remote stimulation techniques for neuronal tissues represents a challenging goal. Among the potential methods, mechanical stimuli are the most promising vector to convey information non-invasively into intact brain tissue. In this context, selective mechano-sensitization of neuronal circuits would pave the way to develop a new cell-type specific stimulation approach. We report he...

Circadian clocks drive ∼24 h rhythms in tissue physiology. They rely on transcriptional/translational feedback loops driven by interacting networks of clock complexes. However, little is known about how cell-intrinsic circadian clocks sense and respond to their microenvironment. Here, we reveal that the breast epithelial clock is regulated by the mechano-chemical stiffness of the cellular micro...