Adjuvant high dose IVIgs are being used increasingly in a range of immune-mediated and auto-immune diseases. Although numerous immunomodulatory mechanisms have been suggested, the exact mechanisms of action are poorly understood. The efficacy of IVIg in certain diseases has been proven in clinical trials, in so far as IVIg is approved as the therapy of choice for Kawasaki syndrome and idiopathi...

introduction: some dental sealers have neurotoxic effects on neuronaltissues. these effects appear to be mediated through the inhibition of ionic channels. intracellular recording was performed on neuronal cells tocharacterize the underlying ionic mechanisms of neurotoxicity induced by roth 801. materials and methods: experiments were carried out on f1 neuronal soma membrane located in the righ...