Journal of Immunology. Dec 2006; 177: 8667 – 8675 Candida albicans is a common cause of nosocomial infections whose virulence depends on the reversible switch from blastoconidia to hyphal forms. Neutrophils (or polymorphonuclear leukocytes (PMNs)) readily clear blastoconidia by phagocytosis, but filaments are too long to be ingested. Mechanisms regulating immune recognition and response to fila...

The effect of ouabain on exocytotic and nonexocytotic norepinephrine release was investigated in perfused rat and guinea pig hearts. The overflow of endogenous norepinephrine and its neuronal metabolite 3,4-dihydroxyphenylethyleneglycol (DOPEG) was determined by highpressure liquid chromatography. DOPEG served as the indicator of free axoplasmic norepinephrine concentrations. The overflow of th...

The nitrogen-containing bisphosphonates (N-BPs), alendronate and risedronate, are the only pharmacologic agents shown to prevent spine and nonvertebral fractures associated with postmenopausal and glucocorticoid-induced osteoporosis. At the tissue level, this is achieved through osteoclast inhibition, which leads to reduced bone turnover, increased bone mass, and improved mineralization. The mo...

Die starke Stimulierung der Synthese möglicher­ weise saurer Kernproteine unter Insulin läßt sich mit diesen Befunden in Einklang bringen. Die Aufgaben der sauren Kernproteine bei der Regulation auf Genebene sind in zunehmendem Maß Gegenstand der Spekulation. Einige Polyanionen, besonders saure Proteine, Polyäthylensulfonat und RNA 20-23, steigern die endogene RNA-Synthese von isoliertem Chroma...

Five experiments that support this scheme are presented. 1. The conversion of 3-T-isocitrate to citrate at early times gives T-citrate with no loss of tritium. 2. When the conversion of 2-T-citrate to isocitrate is brought to completion by trapping the isocitrate with isocitrate dehydrogenase, and the oc-ketoglutarate formed with glutamate dehydrogenase, the amount of tritium found in the gluta...

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Rituximab is a mainstay in the therapy for a broad variety of B-cell malignancies. Despite its undeniable therapeutic value, we still do not fully understand the mechanisms of action responsible for rituximab's anti-tumor effects. Direct signaling, complement-mediated cytotoxicity (CMC), and antibody-dependent cellular cytotoxicity (ADCC) all appear to play a role in rituximab efficacy. In vitr...

The parasites of genus Leishmania are the causative agents of one of the most widespread and devastating diseases. According to follow-up data, these medications may provoke adverse drug reactions, drug resistance, relapse as well as financial burden. The mechanism of action of opioid drugs are primarily exerted via transmembrane G-protein coupled receptors. One of the potent synthetic immunomo...