. Tl:is paper des?ribes a scat tering method for meas uring microwave diff ractio n fi elds uSlllg light modulatIO n. A small photoelectric cell is suspended in t he fi eld as a scatterer upon whi ch light p ulses shine at an audi o rate. Only t he siO"nal scattered back by t he scat~ terer is modulated. A co herent detecto r is used which has ban outp ut voltage proportional to t he square of ...

Boron doped nanocrystalline diamond is known as a remarkable material for the fabrication of sensors, taking advantage of its biocompatibility, electrochemical properties, and stability. Sensors can be fabricated to directly probe physiological species from biofluids (e.g. blood or urine), as will be presented. In collaboration with electrophysiologists and biologists, the technology was adapte...

New relations for and interrelations between the current responses of different microelectrode arrays are presented. Interdigitated microelectrode arrays (IDAs: alternating cathodes and anodes) and uniform microband electrode arrays (MEAs: only cathodes or anodes) are treated, and miniaturized systems with planar band electrodes or hemicylinder electrodes are discussed. A common basis was found...

INTRODUCTION Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. During the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. Ama...

Using Micro-Electro-Mechanical-Systems (MEMS) technologies, we have developed silicon wafer-based platinum microelectrode arrays (MEAs) modified with glutamate oxidase (GluOx) for electroenzymatic detection of glutamate in vivo. These MEAs were designed to have optimal spatial resolution for in vivo recordings. Selective detection of glutamate in the presence of the electroactive interferents, ...

Functional connectivity of in vitro neuronal networks was estimated by applying different statistical algorithms on data collected by Micro-Electrode Arrays (MEAs). First we tested these "connectivity methods" on neuronal network models at an increasing level of complexity and evaluated the performance in terms of ROC (Receiver Operating Characteristic) and PPC (Positive Precision Curve), a new...

Today, multielectrode arrays (MEAs) capture neuronal spike streams in real time, thus providing dynamic perspectives into brain function. Mining such spike streams from these MEAs is critical toward understanding the firing patterns of neurons and gaining insight into the underlying cellular activity. However, the acquisition rate of neuronal data places a tremendous computational burden on the...

In Parkinson’s Disease, pacemaker-like stimulation of the Subthalamic Nucleus (STN) at a frequency near 130 Hz can suppress symptoms like tremor, rigidity and bradykinesia. However, the mechanism by which this so-called Deep Brain Stimulation (DBS) exerts its effect is unknown. In order to increase our understanding of the network in which the STN is involved (the basal ganglia, among others in...

Introduction: Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. During the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. Am...

Abstract Background Managed Entry Agreements (MEAs) are increasingly used to address uncertainties arising in the Health Technology Assessment (HTA) process due immature evidence of new, high-cost medicines on their real-world performance and cost-effectiveness. The literature remains inconclusive HTA decision-making factors that influence utilization MEAs. We aimed assess if uptake MEAs differ...