Fetal hemoglobin (HbF) is a recognized modulator of sickle cell disease (SCD) severity. HbF levels are strongly influenced by genetic variants at three major genetic loci, Xmn1-HBG2, HMIP-2, and BCL11A, but the effect of these loci on the hematological phenotype in SCD, has so far not been investigated. In a cohort of individuals with SCD in Tanzania (HbSS and HbS/β° thalassemia, n = 726, aged ...

Cancer is a cellular change caused by uncontrolled cell growth and division. This disease develops from the of abnormal cells that have potential to invade or spread other parts body. The aim this study was investigate relationship between blood parameters (e.g., Mean corpuscular volume (MCV), hemoglobin (MCH), Corpuscular Hemoglobin Concentration (MCHC), Haemoglobin (HGB), White Blood Cell (WB...

Cadmium is one of the toxic, hazardous metals widely dispersed in the environment in high levels. The aim of the present study is to evaluate the role of lycopene on hematological parameters in cadmium exposed mice. Albino mice were divided into four groups. Group I were control mice, group II received cadmium (0.32mg/kg bw) only, group III received olive oil (20mg/kg bw) only and group IV rece...

Malachite green is an extensively used biocide in the aquaculture industry world-wide. It has been widely used due to lack of a proper alternative. Pyceze, however, is a pharmaceutical alternative to malachite green, with bronopol as its active ingredient. The catfish Heteropneustes fossilis were exposed for four days to 1/5th of LC50 values of each of malachite green (0.24mg/l) and Pyceze (0.4...

A pharmacokinetics (PK)/pharmacodynamics (PD) model was developed to describe the tolerance and rebound for reticulocyte (RET) and red blood cell (RBC) counts and the hemoglobin (Hb) concentrations in blood after repeated intravenous administrations of 1350 IU/kg of recombinant human erythropoietin (rHuEPO) in rats thrice weekly for 6 weeks. Drug concentrations were described by using a quasi-e...

OBJECTIVE To verify the prevalence of anemia, iron deficiency anemia and iron deficiency in infants, at a Public Health Unit in the city of Goiânia-Brazil; to analyze and to correlate the hematologic and biochemical variables. METHODS A cross-sectional study was carried out. One hundred and ten full-term infants of the 120 mothers interviewed were included. The infants aged between six and tw...

The present study was aimed with study the haematological alteration in Fasciola hepatica infected goats. The study duration was one year in which summer, rainy and winter season included. Total 60 goats were included for this study. Goats were divided in two groups one was slaughter house and second was house hold. Blood samples were taken from the jugular vein into evacuated EDTA tubes and st...

background: sickle cell disease is a genetic disorder of hemoglobin causing myriad of pathology including anemia. the purpose of this study was to evaluate the baseline values of steady state hemoglobin and packed cell volume as a guide to managing the early recognition of hemolytic crises in sickle cell anemia. methods: a cross-sectional study was conducted among the sickle cell patients atten...

Background: Workers in different occupational positions experience significant Cu exposures, however, Cu toxicity has not been fully studied as compared to other heavy metals. In the present study, hematological and hepatic alterations have been investigated among copper mine workers. Materials and Methods: This descriptive study was conducted in a copper mine in west of Iran, on 402 copper mi...

Article history: Received on: 03/07/2013 Revised on: 19/07/2013 Accepted on: 25/07/2013 Available online: 30/07/2013 To investigate the effect of methanolic root extract (MREt) of Rauwolfia serpentina on hyperglycemic, haematinic and antioxidative dysfunction associated with alloxan-induced diabetes. Mice were divided into normal and alloxan-induced diabetic groups, the second group was sub-div...