Toll-like receptor 4 (TLR4) and its coreceptor, myeloid differentiation factor-2 (MD-2), are key in recognition of lipopolysaccharide (LPS) and activation of proinflammatory pathways. Here we tested the hypothesis that TLR4 and its coreceptor MD-2 play a central role in nonalcoholic steatohepatitis (NASH) and liver fibrosis in nonalcoholic fatty liver disease. Mice of control genotypes and thos...

To promote the conservation and utilization of Catalpa fargesii f. duclouxii (Huangxinzimu) germplasm resources, a total 252 accessions were used to construct preliminary core collection according phenotypic traits single nucleotide polymorphism (SNP) markers. In this study, 24 traits, namely, 9 quantitative 15 qualitative investigated. The C. was constructed remove redundant samples from colle...

PURPOSE This study was aimed at evaluating sirtuin 4 (Sirt4) levels in obese individuals, in relation to their adherence to the Mediterranean diet (MD), a healthy dietary pattern characterized by high antioxidant capacity, and markers of visceral fat storage. SUBJECTS/METHODS Forty-three obese patients (44% males; BMI: 36.7-58.8 kg/m2) were consecutively included. PREvención con DIeta MEDiter...

• Adherence to a Mediterranean diet is associated with reduced platelet and leukocyte counts. • The observed associations are partially explained by the high dietary fiber and antioxidant content of the Mediterranean diet. Platelet (PLT) and white blood cell (WBC) counts are 2 markers of inflammation and have been linked to the risk for cerebrovascular and coronary heart disease. A Mediterranea...

Results of limnological investigation of lake Ashura showed that air and water temperatures were 31.5 ± 0.25oC and 30.0 ± 0.45oC, respectively in the month of April, 2011. pH, alkalinity, conductivity, dissolved oxygen and TDS of water were 7.11 ± 0.02, 2.96 ± 0.58 meq/l, 760.67 ± 8.08 μS/cm, 7.72 ± 0.41 mg/l and 104.67 ± 1.53 mg/l, respectively. The concentration of NO3-N, SRP and SRS were 63....

background: mediodorsal (md) thalamic nucleus, which is considered to take place between extra pyramidal and limbic feedback circuit, receives projective fibers from ventrolateral neurons of reticular part of substantia nigra (snr). in order to better understand the influence and chemical reaction of these fibers upon md nucleus, the morphology and synaptology of them were examined in the prese...