نتایج جستجو برای: mcm 41tmspdeta

تعداد نتایج: 3500  

2015
Renaud Hédouin Olivier Commowick Aymeric Stamm Christian Barillot

Multi-compartment diffusion models (MCM) are increasingly used to characterize the brain white matter microstructure from diffusion MRI. We address the problem of interpolation and averaging of MCM images as a simplification problem based on spectral clustering. As a core part of the framework, we propose novel solutions for the averaging of MCM compartments. Evaluation is performed both on syn...

2007
Richard E. Petty Pablo Briñol Kenneth G. DeMarree

We present a Meta–Cognitive Model (MCM) of attitudes. According to the MCM, an attitude object can be associated with both positive and negative evaluations that can be detected with modern implicit (automatic) measures of attitudes. These evaluative associations can be further associated with validity tags that are also consulted when completing deliberative attitude measures. We explain how t...

Hadi Ranjkeshzadeh, Leila Majedi, Nowruz Delirezh, Siamak Asri Rezaei,

Background: Dendritic cells (DC) induce tumor or pathogen-specific T cell responses in humans. Several laboratories have developed culture systems, including maturation factors for human DC from peripheral blood monocytes. We comprehensively compared standard maturation stimulus, an autologous monocyte-conditioned medium (MCM), with heparin for their ability to promote uniformly mature DC that ...

Journal: :Nucleic acids research 2003
Ian Grainge Sarah Scaife Dale B Wigley

The eukaryotic pre-replication complex is assembled at replication origins in a reaction called licensing. Licensing involves the interactions of a variety of proteins including the origin recognition complex (ORC), Cdc6 and the Mcm2-7 helicase, homologues of which are also found in archaea. The euryarchaeote Archaeoglobus fulgidus encodes two genes with homology to Orc/Cdc6 and a single Mcm ho...

Journal: :Cancer research 2010
Shahana Majid Altaf A Dar Sharanjot Saini Yi Chen Varahram Shahryari Jan Liu Mohd Saif Zaman Hiroshi Hirata Soichiro Yamamura Koji Ueno Yuichiro Tanaka Rajvir Dahiya

The minichromosome maintenance (MCM) gene family is essential for DNA replication and is frequently upregulated in various cancers. Here, we examined the role of MCM2 in prostate cancer and the effect of microRNA-1296 (miR-1296), genistein, and trichostatin A (TSA) on the MCM complex. Profiling results showed that expression of MCM genes was higher in tumor samples. Genistein and TSA significan...

1999
Daksh Lehther Sachin S. Sapatnekar

Multi-Chip Modules (MCM's) provide a medium for integration of several bare dies on a multi-layer substrate. MCM technology has gained popularity in recent years with the promise of orders of magnitude reduction in inter-chip delay and power dissipation over single chip packaging [2]. By virtue of a faster interconnect MCM's aim at alleviating, to a large extent, the bottleneck o ered by conven...

Journal: :Cancer research 1998
P Fishman S Bar-Yehuda L Vagman

In this study, we investigated the basis of the resistance of muscles to tumor metastases. We found that a low molecular weight fraction (Mr <3000) of skeletal muscle cell-conditioned medium (MCM) markedly inhibits the proliferation of carcinoma, sarcoma, or melanoma cell lines in vitro. The MCM exerts a cytostatic effect on tumor cell growth and arrests the cells in G0/G1 of the cell cycle. Ho...

2001
Ken Gilleo Thomas Cinque Steven Corbett Christopher Lee

Electronic Polymers are solving new problems in the technology revolution brought on by the quest for ultimate computing performance. Computing power will increase by an order of magnitude during this decade and MultiChip Modules (MCM) will be the main enabling technology. The MCM strategy of closely packing bare die onto inorganic or polymer substrates demands new materials, especially for die...

2008
Gyri Teien Haugland Nozomi Sakakibara Angel L. Pey Claire R. Rollor Nils-Kåre Birkeland Zvi Kelman

The minichromosome maintenance (MCM) proteins are thought to function as the replicative helicases in archaea. In most archaeal species studied, the interaction between MCM and the initiator protein, Cdc6, inhibits helicase activity. To date, the only exception is the helicase and Cdc6 proteins from the archaeon Thermoplasma acidophilum. It was previously shown that when the Cdc6 protein intera...

2016
Tom D Deegan Joseph TP Yeeles John FX Diffley

The initiation of eukaryotic DNA replication requires the assembly of active CMG (Cdc45-MCM-GINS) helicases at replication origins by a set of conserved and essential firing factors. This process is controlled during the cell cycle by cyclin-dependent kinase (CDK) and Dbf4-dependent kinase (DDK), and in response to DNA damage by the checkpoint kinase Rad53/Chk1. Here we show that Sld3, previous...

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