نتایج جستجو برای: mb231 cells

تعداد نتایج: 1383552  

2013
Ruben D. Motrich Gonzalo M. Castro Beatriz L. Caputto

A shared characteristic of tumor cells is their exacerbated growth. Consequently, tumor cells demand high rates of phospholipid synthesis required for membrane biogenesis to support their growth. c-Fos, in addition to its AP-1 transcription factor activity, is the only protein known up to date that is capable of activating lipid synthesis in normal and brain tumor tissue. For this latter activi...

Afsaneh Nezhadhosseini Alireza Haghighi, Amin Dinarvand Fereidon Nirouzad Hossein Dehghani, Maliheh Entezari, Mehrdad Hashemi, Mohammad Hossein Khosropanah Sepideh Khatamsaz Sima Hashemi

Cancer is one of the main cause of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. The identification of new cytotoxic drug with low sid effects on immune system has developed as important area in new studies of immunopharmacology. Curcumin is a natural polyphenol with anti-oxidative, anti-inflammatory and anti-cancer properties...

2012
Kuo-Ching Chao Hui-Tai Yang Min-Wei Chen

The purpose of this study was to investigate how human umbilical cord mesenchymal stem cells (HUMSCs) affect breast cancer tumourigenesis. To observe the influence of HUMSCs on tumourigenesis in vitro, we performed a co-culture of MDA MB-231 breast cancer cells with HUMSCs, and a result of HUMSCs on tumourigenesis in vivo was achieved by injection of HUMSCs into nonobese diabetic/severe combine...

Journal: :Chemical research in toxicology 2017
Mariangela Librizzi Fabio Caradonna Ilenia Cruciata Janusz Dębski Supojjanee Sansook Michał Dadlez John Spencer Claudio Luparello

Jay Amin hydroxamic acid (JAHA; N8-ferrocenylN1-hydroxy-octanediamide) is a ferrocene-containing analogue of the histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA). JAHA's cytotoxic activity on MDA-MB231 triple negative breast cancer (TNBC) cells at 72 h has been previously demonstrated with an IC50 of 8.45 μM. JAHA's lethal effect was found linked to perturbations of ...

2016
Kristina Cotter Rachel Liberman GeHong Sun-Wada Yoh Wada Dennis Sgroi Stephen Naber Dennis Brown Sylvie Breton Michael Forgac

The vacuolar (H+)-ATPases (V-ATPases) are a family of ATP-driven proton pumps that acidify intracellular compartments and transport protons across the plasma membrane. Previous work has demonstrated that plasma membrane V-ATPases are important for breast cancer invasion in vitro and that the V-ATPase subunit a isoform a3 is upregulated in and critical for MDA-MB231 and MCF10CA1a breast cancer c...

Journal: :the iranian journal of pharmaceutical research 0
abbas zare mirakabadi department of venomous animals and antivenom production, razi vaccine and serum research institute, karaj, iran. zahra shahramyar department of venomous animals and antivenom production, razi vaccine and serum research institute, karaj, iran. hasan morovvati quality control department, razi vaccine and serum research institute, karaj, iran. mohsen lotfi quality control department, razi vaccine and serum research institute, karaj, iran. ali nouri electron microscopy department, razi vaccine and serum research institute, karaj, iran.

our previous studies revealed an inhibitory effect of icd-85 (venom derived peptides) on breast cancer cell line mda-mb231. icd-85 was also confirmed by in-vivo studies to suppress the breast tumor in mice. however, the exact mechanism of icd-85 was unknown. hence, the present study was undertaken to assess the mechanism of icd-85 effect as an anti-proliferative agent of cancer cells. the effec...

2012
Cécile Pierre-Eugene Patrick Pagesy Tuyet Thu Nguyen Marion Neuillé Georg Tschank Norbert Tennagels Cornelia Hampe Tarik Issad

BACKGROUND In diabetic patients, the pharmacokinetics of injected human insulin does not permit optimal control of glycemia. Fast and slow acting insulin analogues have been developed, but they may have adverse properties, such as increased mitogenic or anti-apoptotic signaling. Insulin/IGF1 hybrid receptors (IR/IGF1R), present in most tissues, have been proposed to transmit biological effects ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید