ObjectivesDevelopments in both technique and technology have enabled surgeons to perform the maze procedure via right minithoracotomy (RMT) treat atrial fibrillation (AF). This study aimed clarify outcomes of modified cryomaze RMT approach compared with sternotomy approach.MethodsThe cohort comprised 803 consecutive patients who underwent a (130 673 sternotomy) for paroxysmal AF persistent from...

Although hippocampal neurogenesis has been described in many adult mammals, the functional impact of this process on physiology and behavior remains unclear. In the present study, we used two independent methods to ablate hippocampal neurogenesis and found that each procedure caused a limited behavioral deficit and a loss of synaptic plasticity within the dentate gyrus. Specifically, focal X ir...

The Mas protooncogene is a maternally imprinted gene encoding an orphan G protein-coupled receptor expressed mainly in forebrain and testis. Here, we provide evidence for a function of Mas in the central nervous system. Targeted disruption of the Mas protooncogene leads to an increased durability of long term potentiation in the dentate gyrus, without affecting hippocampal morphology, basal syn...

Isolation of the pulmonary veins has been used as surgical treatment for atrial fibrillation (AF) from the early 90s, as it was incorporated in the Maze procedure. With the evidence that triggers form this area can induce AF, the Maze III procedure has been adapted and modified towards a single lesion around the pulmonary veins for the treatment of paroxysmal and chronic AF in some centers. New...

• A new row was added for “Transcatheter PVI vs. PV Antrum Radial Linear Ablation” to reflect the interventions used in a new included study. The SOE was Insufficient for all outcomes. • The two comparisons (1) “Surgical Maze vs. Standard of Care (Mitral Valve Surgery) or AADs” and (2) “PVI at the Time of Cardiac Surgery vs. Cardiac Surgery Alone or in Combination with AADs or Catheter Ablation...

The long-term success rate of the Cox maze III procedure is excellent, although it has not been widely adopted because of the need for extensive incisions of the atria. In this study, we report our experience with a closed biatrial procedure using bipolar radiofrequency (RF) ablation for treating atrial fibrillation (AF) during non-mitral cardiac operations. Beginning in December 2004, a total ...

OBJECTIVE Although the classical Cox-Maze III is the gold standard surgical therapy with a proven efficacy in the treatment of atrial fibrillation (AF), complexity of this procedure has resulted in a search for a simpler, less invasive and more cost-effective method. In this study we evaluated the results of cryosurgical ablation in the treatment of chronic AF in patients undergoing concomitant...

BACKGROUND If drug refractoriness to paroxysmal atrial fibrillation (PAF) occurs, arrhythmia surgery that involves channelling and the exclusion of specific atrial areas can abolish atrial fibrillation. The purpose of this study was to establish the effectiveness and safety of maze III surgery to abolish PAF. METHODS AND RESULTS Surgery was performed in 41 selected patients who had long-stand...