A porcine skin model was developed to characterize the dose-dependent response to high-dose radiation. The dorsal skin of a mini pig was divided into four paraspinal sections, with 11 small irradiation fields (2 cm × 2 cm) in each section, and a single fraction of 15, 30, 50 or 75 Gy was delivered to each section using a 6 MeV electron beam. A spectrophotometer measured gross skin changes, and ...

PURPOSE PF299804 is a potent, orally available, irreversible inhibitor of tyrosine kinase human epidermal growth factor receptors (HER) 1 (EGFR), HER2, and HER4. This first-in-human study investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF299804 in patients with advanced solid malignancies. EXPERIMENTAL DESIGN PF299804 was administered once daily continuously (...

Development of risk assessment methods for skin sensitization in the absence of toxicological data generated in animals represents a major scientific and technical challenge. The first step in human skin sensitization induction is the transport of sensitizer from the applied dose on the skin surface to the epidermis, where innate immune activation occurs. Building on the previous development of...

background: for radiotherapy of total skin including sub-cutaneous tissue up to a depth of 3 cm on the entire left leg of an adult (angiosarcoma skin), a complex treatment with multiple stationary electron fields was planned at our clinic. the details of dosimetry, clinical dose measurements are presented. materials and methods: the treatment planned with 6 overlapping 9 mev electron fields in ...

BACKGROUND The methotrexate (MTX) polyglutamate assay has been validated in adults with arthritis. OBJECTIVE We sought to assess clinical response rates and the value of the methotrexate polyglutamate assay in MTX-treated children with inflammatory skin diseases. METHODS In this retrospective review, 46 MTX-treated children with a diagnosis of atopic dermatitis, psoriasis, or psoriasis-ecze...

Concentrations of trimethoprim and sulfamethoxazole in plasma, cantharidin-induced skin blister fluid and theoretical peripheral compartment were determined in twelve male subjects suffering from bacterial skin diseases after a single oral dose of 0.32 g of trimethoprim and 1.6 g of sulfamethoxazole. Maximum trimethoprim concentrations of 8.5 +/- 1.1 micromol/l in plasma, 5.6 +/- 0.8 micromol/l...

computed tomographyrepresents about 10% of all diagnostic radiology procedures, but it isresponsible for almost 50% - 60% of exposure from diagnostic procedures. inhead ct, other critical organs such as eye lenses and thyroids are in theradiation field. therefore, dose assessment in these organs is very important.the aim of this study is to estimate the absorbed dose in critical organs ofpatien...

Background: Accelerated partial breast irradiation via interstitial balloon brachytherapy is a fast and effective treatment method for certain early stage breast cancers however skin, chest wall and Lung doses are correlated with toxicity in patients treated with breast brachytherapy.Objective: To investigate the percentage of the dose received by critical organ (skin), thermoluminescence detec...