Pleomorphic adenoma (PA) is the most common neoplasm of salivary glands and consists epithelial mesenchymal components. Although a benign lesion, it harbors potential for recurrence malignant transformation. Also, due to its histological diversity unpredictive behavior PA can represent both diagnostic therapeutic challenge. Matrix metalloproteinases (MMPs) are well known modifiers extracellular...

Staphylococcus aureus is responsible for most bacterial wound infections. Antibiotics are the first-line treatment; however, their indiscriminate use led to emergence of resistance. Alternative therapeutic options beyond antibiotic treatment required. Our study aimed evaluate and compare healing parameters antibacterial activity Jojoba Citrullus colocynthis oil extracts in In-vivo assessment in...

Inflammation plays a critical role in the development of cancer. Matrix Metalloproteinase (MMP) functions in the remodeling of the extracellular matrix that is integral for many normal and pathological processes such as morphogenesis, angiogenesis, tissue repair, and tumor invasion. The tissue inhibitor of metalloproteinases (TIMPs) family regulates the activity of multifunctional metalloprotei...

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) regulate proteolysis of the extracellular matrix and other extracellular proteins, including growth factors and their receptors. The aberrant expression of these genes is common in most cancers. We profiled the RNA levels of every human MMP and TIMP in a variety of cell types (fibroblast, endothelial, hematopoi...

Extracellular matrix metalloproteinase inducer (EMMPRIN), also known as basigin or CD147, is a glycoprotein that is enriched on the surface of tumor cells and stimulates production of several matrix metalloproteinases by adjacent stromal cells. In this study, we have found that EMMPRIN not only stimulates the production of interstitial collagenase (MMP-1) but also forms a complex with MMP-1 at ...

Osteoarthritis (OA) is a degenerative joint disease associated with inflammation. Polygonatum sibiricum polysaccharide (PSP) major group of active components isolated from broad activities including anti-inflammatory effect. However, the role PSP in OA unclear. In present study, we aimed to investigate effects on IL-1β-induced inflammatory response primary human chondrocytes. The results showed...

Three members of the SIBLING family of integrin-binding phosphoglycoproteins (bone sialoprotein, BSP; osteopontin, OPN; and dentin matrix protein-1, DMP1) were recently shown to bind with high affinity (nM) and to activate 3 different matrix metalloproteinases (MMP-2, MMP-3, and MMP-9, respectively) in vitro. The current study was designed to document the possible biological relevance of the SI...

In the pathogenesis of dilated cardiomyopathy (DCM) in Emery-Dreifuss muscular dystrophy (EDMD) matrix metalloproteinases (MMPs) are supposed to be involved and may have diagnostic/prognostic value. Serum levels of MT1-MMP, MMP-2 and MMP-9 were quantified by ELISA and zymography in 22 EDMD patients and 15 age-matched controls. In the autosomal-dominant EDMD MMP-2 and MT1-MMP were increased in a...

Keratinocyte hyperproliferation, inflammatory infiltrates, neoangiogenesis and alterations in cytokine levels are hallmarks of psoriatic skin. Matrix metalloproteinases (MMPs) have been associated with the remodeling of the extracellular matrix during inflammation, neovascularization, and malignant transformation. We have previously shown that particularly MMP-12 is abundantly expressed by macr...

Generalized periodontitis is one of the most widespread human stomatological diseases; it diagnosed in 11.0 % world's population. Despite recognition microbial factor as leading its etiopathogenesis, antimicrobial treatment gingivitis, added with removal dental plaque, does not prevent further development periodontitis. Dysbacteriosis causes inflammation which leads to an increase proteolysis p...