Excessive neutrophil infiltration in vital organs is life-threatening to patients who suffer from sepsis. We identified a critical role of exogenous carbon monoxide (CO) in the inhibition of neutrophil infiltration during lipopolysaccharide (LPS)-induced sepsis. CO delivered from carbon monoxide-releasing molecule 2 (CORM-2) dramatically increased the survival rate of C57BL/6 mice subjected to ...

Although carbon monoxide (CO) has traditionally been viewed as a toxic gas, increasing evidence suggests that it plays an important homeostatic and cytoprotective role. Its therapeutic use, however, is limited by the side effects associated with CO inhalation. Recently, transition metal carbonyls have been shown to be a safe and effective means of transporting and releasing CO groups in vivo. T...

Carbon monoxide, a classical respiratory inhibitor, also exerts vasodilatory, antiinflammatory and anti-apoptotic effects. COreleasing molecules (CO-RMs) have therapeutic value, increasing phagocytosis and reducing sepsis-induced lethality. Here we identify for the first time the bacterial targets of CORM-3, Ru(CO)3Cl(glycinate), a ruthenium-based carbonyl that liberates CO rapidly under physio...

Carbon monoxide (CO) is well-known as toxic gas and intrinsic signaling molecule such as neurotransmitter and blood vessel relaxant. Recently, it has been reported that low concentration of CO exerts therapeutic actions under various pathological conditions including liver failure, heart failure, gastric cancer, and cardiac arrest. However, little has been known about the effect of CO in neurod...

Production of Saffron (Crocus sativus L.) is expanding in both the traditional and non-native areas Jammu Kashmir, India. A study was carried out to develop a cost-effective production system module at ARSSSS, SKUAST-Kashmir, Pampore determine suitable corm weight planting density for saffron. The treatments current includes 3 levels (W1= < 8g, W2= 8-12g W3 = >12g) 5 densities viz., 15 lakh den...

Carbon monoxide (CO) is endogenously produced by heme oxygenase (HO) and is involved in vascular, neural, and inflammatory responses in mammals. However, the biological activities of CO in nonmammalian vertebrates is unknown. To this extent, we used smooth muscle myography to investigate the effects of exogenously applied CO (delivered via a water-soluble CO-releasing molecule, CORM-3) on isola...

this study was conducted to investigate direct and maternal effects on some economic traits in north iranian native fowls. traits considered were body weight at 1 day of age (bw1), body weight at 8 weeks of age (bw8), body weight at 12 weeks of age (bw12), egg number (en) during the first 12 weeks of laying period, egg weight at 1st day of laying (ew1), mean egg weight at 28th, 30th and 32nd we...

guaiacol peroxidases (gp) are haem-containing enzymes participating in many physiological processes in plants. the expression pattern of these enzymes is organ-specific and developmentally regulated. methods: the presence of gp activity in extract samples, prepared from crocus sativus l. corms that were either dormant or rooting for 3, 6 and 10 days, was investigated. results: kinetic studies r...

Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological ‘gasotransmitter’, in chemistry and biomedicine. CORMs kill bacteria culture animal models, but reportedly benign towards mammalian cells. CORM-2 (tricarbonyldichlororuthenium(II) dimer, Ru2Cl4(CO)6), the first widely commercially available CORM, displays numerous pharmacological, biochemical microbiological a...

Helicobacter pylori is a pathogen that establishes long life infections responsible for chronic gastric ulcer diseases and a proved risk factor for gastric carcinoma. The therapeutic properties of carbon-monoxide releasing molecules (CORMs) led us to investigate their effect on H. pylori. We show that H. pylori 26695 is susceptible to two widely used CORMs, namely CORM-2 and CORM-3. Also, sever...