background: acute lymphoblastic leukemia (all), the most common childhood cancer with a peak incidence in children from 2-5 years old, might be associated with poor prognosis and resistance to therapy in specific cytogenetic backgrounds. foxo3a, a member of the forkhead class 'o' (foxo) transcription factors, is a main downstream target of pi3k/akt pathway which regulates different variety of b...

this research proceeded historical analyzing of currere as autobiographical course in reconceptualist works. therefore, reconceptualist works studied by discourse analyzing. unit of analyzing was sentenced and its level was an explanation. in order to research questions data divided to four categories: meaning of currere, methods of currere, stages of currere and politic and sociologic base in ...

objective: different signaling pathways have been identified that are involved in the cellular response to opiates. the mitogen-activated protein kinase pathway is one of the most important signaling pathways underlying the neuronal response to opiates. micrornas (mirnas) are considered to be post-transcriptional regulators of gene expression with paramount significance, which plays key roles i...

materials and methods an oligogearray® (an oligonucleotide-based gene expression array platform) containing 126 wnt signaling pathway-related genes was used to compare gene expressions between primary hcc and adjacent non-tumorous liver tissues from 10 patients with hcc. selected differential genes were identified with real-time rt-pcr and immunohistochemistry (ihc). in particular, the protein ...

Objective(s): Non-invasive treatment options for retinoblastoma (RB), the most common malignant eye tumor among children, are lacking. Epithelial growth factor receptor (EGFR) accelerates cell proliferation, survival, and invasion of many tumors including RB. However, RB treatment by targeting EGFR has not yet been researched. In the current study, we investigated the effect of EGFR down-regula...

It has been suggested that single nucleotide polymorphisms (SNPs) in genes involved in Toll-like receptors (TLRs) pathway may exhibit broad effects on function of this network and might contribute to a range of human diseases. However, the extent to which these variations affect TLR signaling is not well understood. In this study, we adopted a bioinformatics approach to predict the consequences...

sleep plays a vital role in regulating physiological mechanisms in the human body. nowadays, by the change of lifestyle and as a consequence of longer work hours and increased accessibility to media, sleep disturbance becomes a common problem in modern society. many studies demonstrated that sleep disturbance triggers a systemic low-grade inflammation by increasing the level of several cytokine...

Microsomal triglyceride transfer protein (MTP) is rate limiting for the assembly and secretion of apolipoprotein B-containing lipoproteins. Elevated hepatic MTP mRNA level, presumably as a result of impaired insulin signaling, has been implicated in the pathophysiology of dyslipidemia associated with insulin resistance/type 2 diabetes. In this study, we showed that insulin decreases MTP mRNA le...

neural cell adhesion molecules (ncams) are known to influence memory by affecting neural cell-cell and cell-extracellular matrix junctions. this study investigated the possible role of camp pathway in the expression of hippocampal ncam and its polysialylated derivative (psa-ncam). the following pharmacological tools were employed for manipulation of camp pathway: a) forskolin; the activator of ...