What is Sustainable Manufacturing? Implementing sustainable manufacturing across U.S. production facilities is becoming increasingly important and critical for competitive global manufacturing. Sustainable manufacturing is a topic that has gained national and international awareness, and therefore it is important to understand its core meaning. Although the definition of “sustainable manufactur...

This paper discusses the relationship between modular products and manufacturing. The relationship is based on an expanded definition of modularity which incorporates the potential of modularity based not only on end uses of a product but also on the manufacturing processes. By incorporating this expanded definition of modularity, called manufacturing modularity , into product development, a mo...

An essential part of the planning and control of any manufacturing system is the development of a model of the key processes. The Critical Path Method (CPM) is the most widely used modeling method in construction due to its simplicity. Discrete-event simulation is more versatile than CPM and is well suited to modeling manufacturing processes since these tend to be repetitive, but it lacks the s...

Monoclonal antibodies have proved to be a highly successful class of therapeutic products. Large-scale manufacturing of pharmaceutical antibodies is a complex activity that requires considerable effort in both process and analytical development. If a therapeutic protein cannot be stabilized adequately, it will lose partially or totally its therapeutic properties or even cause immunogenic reacti...

Traditional practice to tolerance design has been based on a sequential approach to design and manufacturing considerations. An integrated approach involving simultaneous selection of design and manufacturing tolerances was introduced in the last decade. Choice of manufacturing processes (or machines) from amongst the alternatives, frequently encountered in different stages of realization of in...

This paper addresses diagnostic information fusion for situations where several diagnostic tools are used to estimate a single system state. These estimates will always disagree to some extent and it is the task of the fusion module to provide an estimate which is more reliable than the best of the diagnostic tools. To that end, a fusion process was developed which performs a weighted average o...

Variation propagation in a multi-station manufacturing process (MMP) is described by the theory of ‘‘Stream of Variation.’’ Given that the measurements are obtained via certain sensor distribution scheme, the problem of whether the stream of variation of an MMP is diagnosable is of great interest to both academia and industry. We present a comprehensive study of the diagnosability of MMPs in th...

Because these reactive sites are pendant (not part of the main backbone chain) there are no weak points on the main chain. This is unlike for example Natural Rubber or SBR, where these necessary reactive sites are along the main chain. This means that reactive entities in the atmosphere (for example Ozone, which is very aggressive) can easily attack and degrade these materials. This also explai...