Primary non-Hodgkin's lymphoma (NHL) of the gastrointestinal tract is the most common extranodal NHL and accounts for 4%-20% of all NHL . Mantle cell lymphoma (MCL) comprises 2.5%-7% of all NHL . Gastrointestinal tract involvement occurred in 20% of MCL, which is commonly manifested as numerous, small, spherical, or hemispherical polyps, termed multiple lymphomatous polyposis (MLP). Hereby we r...

Based on the profound biological insights of the last years into the molecular pathogenesis of mantle cell lymphoma and the clinical introduction of new targeted drugs, with high efficacy and a good safety profile, the therapeutic scenario for this tumor has been shown to be thoroughly favourable. No longer characterized by a uniformly dismal prognosis, mantle cell lymphoma has been revealed as...

Given the significant activity and tolerability of bendamustine, rituximab, and bortezomib in patients with relapsed indolent and mantle cell non-Hodgkin lymphoma, and laboratory studies suggesting synergistic activity, we conducted a multicenter phase 2 study of the bendamustine/bortezomib/rituximab combination. Patients with relapsed or refractory indolent and mantle cell lymphoma with adequa...

Given the significant activity and tolerability of bendamustine, rituximab, and bortezomib in patients with relapsed indolent and mantle cell non-Hodgkin lymphoma, and laboratory studies suggesting synergistic activity, we conducted a multicenter phase 2 study of the bendamustine/ bortezomib/rituximab combination. Patients with relapsed or refractory indolent and mantle cell lymphoma with adequ...

Regulatory T cells (Tregs) play a central role in protecting the host from autoimmune diseases. However, Tregs also pose a major problem to anti-tumor immunity. The expansion and accumulation of these immunosuppressive cells correlate with advanced tumor growth and predict poor disease prognosis. The study aims at evaluation of the clinical role of regulatory T cells in B-cell Non-Hodgkin's lym...

Herein we describe the case of a 64-year old man with a history of mantle cell lymphoma found to have evidence of pulmonary parenchymal involvement by recurrence of his lymphoma. While lung involvement is not necessarily uncommon with Non-Hodgkin's lymphomas as a group, it is very rare for mantle cell lymphoma to involve the lung parenchyma. In addition, the radiographic manifestation of his pu...