The synthesis and characterization of new meso-substituted and -substituted unsymmetrical metallorphyrins has been described. A new modified Alder method was used for the synthesis of unsymmetrical porphyrins. Reaction of these unsymmetrical porphyrins with metal chlorides and nitrates afforded the corresponding metalloporphyrins in high yields with excellent purity. These porphyrins and their...

Charge-transfer (CT) π-complexes are formed between planar porphyrins and 1,4,5,8,9,12-hexaazatriphenylene (HAT) derivatives with large formation constants (e.g., 104 M-1), exhibiting broad CT absorption bands. The unusually large formation constants result from close face-to-face contact between two planar π-planes of porphyrins and HAT derivatives. The redox potentials of porphyrins and HAT d...

A procedure has been developed for the assay of urinary porphyrins. Total porphyrins are extracted from acidified urine into n-butanol. The fluorescence of this solution under ultraviolet illumination gives a preliminary indication of abnormal levels of porphyrins. They are then separated and identified by thin-layer chromatography. Uroporphyrin and coproporphyrin can be qualitatively estimated...

The synthesis and photophysical properties of cyano and ethynyl substituted carbazole-based porphyrins were investigated. The introduction of ethynyl groups induced red shifts, while that of cyano groups induced blue shifts of their absorption bands, which was supported by MO calculations. Ethylenedioxy-appended porphyrins were also prepared via a coupling reaction. The conjugated and electroni...

The aim of this study was to complete research on the porphyrogenic effect of hexabrombenzene (HBB) and tetrabromobisphenol-A (TBBP-A). Experiments were performed on female Wistar rats. The examined compounds were administered in sunflower oil intragastrically in 3 doses. The determination of porphyrins in tissues was carried out by means of high-performance liquid chromatography. Repeated HBB ...

The chains in complex [Mn(TPP)][Mn(TPP)(CN)2] (H2TPP = meso-tetra(4-phenyl)-porphyrin) demonstrate perfect linearity, and are well isolated with the nearest interchain Mn-Mn separation of 12.95 Å. Ferromagnetic coupling is present among adjacent Mn(III) ions, and single-chain magnet (SCM) behaviour is verified.

(9) (a) D. J. Cardin, B. Cetinkaga, and M. F. Lappert, Chem. Reo., 72, 545 (1972); (b) F. A. Cotton and C. M. Lukehart, Progr. Inorg. Chem.. 16.487 (1972). (lO)’B.’Crociani, T. Boschi, M. Nicolini, and U. Belluco, Inorg. Chem., 11, 1292(1972). assigned incorrectly as the benzylic methylene protons, respectively, disappear on treatment with D20, attributable to the N-H group. We revise the struc...

The second-generation quinolone ofloxacin interferes with the screening test of porphyrins. We observed a 20-fold increase in the porphyrin concentration measured in urine of an ofloxacin-treated patient, compared with drug-free normal urine. Two other fluorinated 4-quinolones tested, norfloxacin and ciprofloxacin, had a less marked effect (a twofold increase), whereas the first-generation quin...

Most of the SOD mimics thus far developed belong to the classes of Mn-(MnPs) and Fe porphyrins(FePs), Mn(III) salens, Mn(II) cyclic polyamines and metal salts. Due to their remarkable stability we have predominantly explored Mn porphyrins, aiming initially at mimicking kinetics and thermodynamics of the catalysis of O2(-) dismutation by SOD enzymes. Several MnPs are of potency similar to SOD en...

Parkinson's disease (PD) is an age-related neurodegenerative disease in which the role of reactive oxygen species (ROS) is strongly implicated. The presence of oxidative stress has been detected in human and experimental PD using both direct and indirect indices. Scavenging ROS is, therefore, an important therapeutic avenue for the treatment of PD. Manganic porphyrins are catalytic antioxidants...