Individual variation in gene expression is important for evolutionary adaptation1,2 and susceptibility to diseases and pathologies3,4. In this study, we address the functional importance of this variation by comparing cardiac metabolism to patterns of mRNA expression using microarrays. There is extensive variation in both cardiac metabolism and the expression of metabolic genes among individual...

this research investigates factors of enterprise portals of governmental organizations of iran. methods used in this research are literature and descriptive survey. data was gathered by a researcher-made checklist for enterprise portal factors in the enterprise portals of governmental organizations of iran. the checklist contains six factors that are content management, document management, col...

BACKGROUND This study was designed to investigate general practitioners' knowledge of absolute risk estimation, and whether they used it to guide their management of cardiovascular disease. METHOD A cross sectional postal self administered survey of GPs in the General Practice South Division in southern Tasmania. RESULTS A total of 56-62% of responders correctly answered knowledge questions...

There are approximately 1.3 million cases of neonatal sepsis reported worldwide with deaths occurring more commonly in preterm and low-weight newborns. Neonatal is the third major cause resulting 203,000 per year. It divided into two subtypes based on time occurrence: early-onset (ENS), within first 72 hours birth usually due to perinatal risk factors, late-onset (LOS) after week life up 28th d...

Several  studies  have  indicated  that  the  range  and  linguistics  expressions  of  external modifiers  available  in  one  language  differ  from  those  available  in  another  language.  The present study aims to investigate the cross-cultural differences and similarities with regards to  the  realization  of  request  external  modifications.  To  this  end,  30  Iraqi  and  30  Malay u...

The purpose of this study was to characterize the hepatobiliary disposition of timosaponin B2 (TB-2), a natural saponin. Although TB-2 has multiple pharmacologic activities, the mechanism of its hepatobiliary disposition has not been explored. Because the metabolism of TB-2 is limited and the accumulation of TB-2 in primary hepatocytes is highly temperature dependent (93% of its accumulation is...

Organic anion transporting polypeptides (rodents, Oatps; human, OATPs) are primarily involved in the transmembrane transportation of a wide range of endogenous and exogenous compounds. Multiple mouse Oatp1 isoforms are closely located on chromosome 6, where each isoform shows distinct tissue distribution; Oatp1b2, Oatp1a6, and Oatp1c1 are expressed exclusively in the liver, kidney, and cerebrum...