Cardiac metastasis of germ cell tumors is extremely rare, particularly in females. We report a case of a 26-year-old previously healthy woman who presented with a 5-month history of abdominal pain, weight loss, fever, generalized lymphadenopathy, and acanthosis nigricans. Biopsy of cervical lymph nodes revealed a poorly differentiated neoplasm. Immunohistochemical staining was positive for alph...

We show with transgenic mice that targeted overexpression of glial cell line-derived neurotrophic factor (GDNF) in undifferentiated spermatogonia promotes malignant testicular tumors, which express germ-cell markers. The tumors are invasive and contain aneuploid cells, but no distant metastases have been found. By several histological, molecular, and histochemical characteristics, the GDNF-indu...

Alterations of C-Kit and Bcl-2 have been shown to play important roles in many types of human cancers. Although there are emerging studies of C-Kit in testicular cancer biology, the significance of Bcl-2 in testicular neoplasms has not been well understood. We studied C-Kit and Bcl-2 expressions by immunohistochemistry in 18 testicular cancers including 8 seminomas, 7 mixed germ cell tumors, 1 ...

INTRODUCTION Testicular tumors can be classified as seminomatous and non-seminomatous germ-cell tumor (NSGCT) types. Mixed germ cell tumors contain more than one germ cell component and are much more common than any of the pure histologic forms representing 32%-60% of all germ cell tumors. The composition of these tumors varies. Here we present a rare case of a mixed germ cell tumor composed of...

Germ cell tumors which arise mainly in pediatric and adolescent age group, account for 30% of all ovarian tumors, but constitute only 5% of all malignant ovarian tumors. The presentation is usually insidious with the patient presenting with abdominal swelling and dull aching pain. We report a rare case of a malignant germ cell tumor in a 12-year-old girl who presented with acute abdomen due to ...

background: this research was conducted to introduce a patient with rare ovarian mixed germ cell tumor, presented as molar pregnancy. case presentation: the patient was a 16 year old woman admitted with diagnosis of molar pregnancy. abdominal enlargement was the only complaint. she had a large pelvic mass in physical examination. the first diagnosis was molar pregnancy due to previous ultrasoni...

background and aims. mast cells are one of the characteristic factors in angiogenesis, growth, and metastatic spread of tumors. the distribution and significance of mast cells in many tumors have been demonstrated. however, few studies have evaluated mast cell infiltration in salivary gland tumors. in this study, mast cell counts were evaluated in benign and malignant salivary gland tumors. mat...

Background: Ovarian neoplasm is a type of cancer caused by uncontrolled growth and division cells within the ovary. It common gynecological that affects wide range ages can have various clinical, morphological, histological features. This study aimed to examine relationship between clinical presentation pattern ovarian neoplasm. Methods: cross-sectional conducted among 45 patients admitted depa...

Background: Mixed gonadal dysgenesis is a rare congenital and challenging condition, characterized mainly by 45,X/46,XY karyotype mosaicism, asymmetrical development various internal external genital anatomy. Because of frequent disorder higher risk germ cell neoplasia, management these patients complex requires multidisciplinary approach.Case: We present mixed patient diagnosed with gonadoblas...