In the present investigation, a total number of 22 sheep and 29 goats were surveyed for abnormal masses showed frequently on the skin areas (ears, lips, trunk and perineal region) and eyes (either unilateral or bilateral) of both animals. A characteristic clinical signs represented as cachexia, emaciation, anemia and exophthalmic eye or both eyes. The excised masses appeared grossly as nodular ...

Mature cystic teratomas, also known as dermoid cysts, are composed of a mixture of tissues derived from all three germ layers and constitute about 20% of all ovarian neoplasms. However, malignant transformation in a mature cystic teratoma is an uncommon event occurring only in about 1.8% cases. A variety of tumours can arise within a mature cystic teratoma (most common being squamous cell carci...

Primary malignant melanoma of uterine cervix is a rare and aggressive neoplasm. Approximately 3%-7%of malignant melanomas in women develop within genital tract. Majority occurs in vulva or vagina, but cervix is a rare site. Age range for cervical melanoma is from 19 to 83 years with peak incidence between 60 to 70years. Malignant melanoma presents with vaginal bleeding or discharge and appears ...

Malignant melanoma is among the malignant tumors whose incidence has risen markedly in recent decades. For many years the medical community debated the potential adverse effects of female hormones (whether of exogenous or pregnancy-related endogenous origin), on melanocytic nevi and malignant melanoma. Given that women have been delaying pregnancy until their thirties or forties and that the in...

INTRODUCTION The incidence of cutaneous malignant melanoma is rapidly increasing in Denmark like in other Northern and Western European countries. Our objective was to investigate the characteristics of current patients suffering from cutaneous malignant melanoma. METHODS We evaluated patient and tumour characteristics in a cross-sectional study based on data from the Danish Melanoma Register...

An increasing number of microRNAs have been found to be involved in tumorigenesis, including melanoma tumorigenesis. miR-204-5p is down-regulated and functions as a tumor suppressor in many human malignant tumors. miR-204-5p expression is also decreased in melanoma tissues, but its biological roles and molecular mechanisms in malignant melanoma remain unclear. In this study, the aberrant down-r...

Malignant melanoma is one of the most aggressive malignancies in humans and is responsible for 60-80% of deaths from skin cancers. The 5-year survival of patients with metastatic malignant melanoma is about 14%. Its incidence has been increasing in the white population over the past two decades. The mechanisms leading to malignant transformation of melanocytes and melanocytic lesions are poorly...

Malignant melanoma of soft parts (MMSP), also called clear cell sarcoma of tendons and aponeuroses, is cytogenetically characterized by the t(12;22)(q13;q12) resulting in the chimeric EWSR1/ATF1 gene. MMSP shares a number of morphologic, histologic, and immunohistochemical features with malignant melanoma of the skin, causing diagnostic difficulties in the distinction between MMSP and metastati...

CUTANEOUS MALIGNANT MELANOMA OF THE BREAST CAN BE DIVIDED INTO TWO CATEGORIES: primary and metastatic lesions. Cutaneous malignant melanoma of the breast is a rare tumor, accounting for less than 5% of all malignant melanomas. Clinical features and diagnostic methods of primary cutaneous malignant melanoma of the breast are similar to those arising from other cutaneous areas. Treatment of choic...

P rimary malignant melanoma of the oral cavity is a rare neoplasm. The incidence of oral cavity melanoma is about 0.2%–8.0% of all malignant melanoma cases. Primary lesions arising from oral mucosa occur most frequently on the maxillary gingiva and palate, with the lips being the third most frequent. Melanoma of the tongue is specifically uncommon and represents less than 2% of all oro-nasal me...