Glioma is the main type of malignant brain tumor in adults, and status isocitrate dehydrogenase (IDH) mutation highly affects diagnosis, treatment, prognosis gliomas. Radiographic medical imaging provides a noninvasive platform for sampling both inter intralesion heterogeneity gliomas, previous research has shown that IDH genotype can be predicted from fusion multimodality radiology images. The...

Gliomas comprise a group of heterogeneous primary tumors of the central nervous system that originate from glial cells. Malignant gliomas account for the majority of primary malignant CNS tumors and are associated with high morbidity and mortality. Glioblastoma is the most frequent malignant glioma, and despite recent advances in diagnosis and new treatment options, its prognosis remains dismal...

OBJECT The aim of this study was to develop and characterize a new orthotopic, syngeneic, transplantable mouse brain tumor model by using the cell lines Tu-9648 and Tu-2449, which were previously isolated from tumors that arose spontaneously in glial fibrillary acidic protein (GFAP)-v-src transgenic mice. METHODS Striatal implantation of a 1-microl suspension of 5000 to 10,000 cells from eith...

The malignant glioma is the most common primary human brain tumor. Its tendency to invade away from the primary tumor mass is considered a leading cause of tumor recurrence and treatment failure. Accordingly, the molecular pathogenesis of glioma invasion is currently under investigation. Previously, we examined a gene expression array database comparing human gliomas to nonneoplastic controls a...

BACKGROUND Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor, may have activity in recurrent malignant gliomas. At recurrence some patients appear to develop nonenhancing infiltrating disease rather than enhancing tumor. METHODS We retrospectively reviewed 55 consecutive patients with recurrent malignant gliomas who received bevacizumab and chemotherapy t...

Background: Artificial intelligence (AI) models provide advanced applications to many scientific areas, including the prediction of pathologic grade tumors, utilizing radiology techniques. Gliomas are among malignant brain tumors in human adults, and their efficient diagnosis is high clinical significance. Objectives: Given contribution AI medical diagnoses, we investigated role deep learning d...

Malignant gliomas are the most common primary brain tumors. Despite intensive clinical investigation and many novel therapeutic approaches, average survival for the patients with malignant gliomas is only about 1 year. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown potent and cancer-selective killing activity and drawn considerable attention as a promising therapy for...

Background: Diffuse gliomas are a group of diseases that contain different degrees malignancy and complex heterogeneity. Previous studies proposed biomarkers for certain grades gliomas, but few them have conducted systematic analysis to search molecular markers. Methods: WGCNA was used find significant genes associated with malignant progression diffuse glioma in TCGA sequencing expression data...

Malignant brain tumors remain one of the most complex problem in modern oncology, being among dangerous types cancer not only because their poor prognosis, but also due to immediate consequences for quality life and cognitive functions. It is expected that number such patients will increase as expectancy population increases.The mortality rate with malignant gliomas remains highest all patients...

Previous studies have focused on miRNA expression in brain gliomas. However, both the expression pattern of miRNAs in gliomas of different grades and various miRNAs involved in malignant progression of gliomas are poorly understood. In the present study, we used miRNA microarray-based screening to investigate the miRNA expression profile in gliomas, which was further verified by qRT-PCR in sele...