Base substitution mutations are a major source of genetic novelty and mutation accumulation line (MAL) studies revealed a nearly universal AT bias in de novo mutation spectra. While a comparison of de novo mutation spectra with the actual nucleotide composition in the genome suggests the existence of general counterbalancing mechanisms, little is known about the evolutionary and historical deta...

RÉSUMÉ. Cet article s’intéresse à la problématique de la catégorisation automatique de documents manuscrits en-ligne et plus particulièrement à l’impact de la reconnaissance de l’écriture dans un processus de catégorisation utilisant des méthodes d’apprentissage automatique. Nous comparons les performances obtenues avec des documents issus d’un système de reconnaissance de l’écriture en-ligne e...

Introducción. Los pacientes con diabetes mellitus tipo 2 y obesidad con frecuencia presentan un mal control glucémico. El exceso de peso, la hiperlipemia y la hipertensión a menudo acompañan a la terapia con insulina en estos pacientes. Objetivo. El objetivo principal de nuestro estudio fue evaluar el efecto de la metformina en pacientes obesos con diabetes tipo 2 previamente tratados con otras...

Résumé Dans cet article nous décrivons une approche pour la reconnaissance automatique de la parole (RAP) non native. Nous proposons deux méthodes pour l’adaptation d’un système de reconnaissance automatique de la parole (SRAP) existant. La première se base sur la modification des modèles acoustiques par l’intègration des modèles de la langue maternelle (LM). Les phonèmes de la langue parlée (L...

This paper is devoted to a conditional stability estimate related to the ill-posed Cauchy problems for the Laplace’s equation in domains with Lipschitz boundary. It completes the results obtained in [4] for domains of class C. This estimate is established by using an interior Carleman estimate and a technique based on a sequence of balls which approach the boundary. This technique is inspired f...

The Mal de Debarquement syndrome (MdDS) generally follows sea voyages, but it can occur after turbulent flights or spontaneously. The primary features are objective or perceived continuous rocking, swaying, and/or bobbing at 0.2 Hz after sea voyages or 0.3 Hz after flights. The oscillations can continue for months or years and are immensely disturbing. Associated symptoms appear to be secondary...

The mal de debarquement syndrome (MdDS) is a movement disorder, occurring predominantly in women, is most often induced by passive transport on water or in the air (classic MdDS), or can occur spontaneously. MdDS likely originates in the vestibular system and is unfamiliar to many physicians. The first successful treatment was devised by Dai et al. (1), and over 330 MdDS patients have now been ...