Magnesium, which acts as an antagonist of N-methyl-D-aspartate (NMDA) subtype of glutamate receptors, exerts antidepressant-like activity in animal models of depression. The present study was undertaken to elucidate the influence of sildenafil, a phosphodiesterase type 5 inhibitor, on the anti-immobility action of magnesium in the forced swim test in mice. Swim sessions were conducted by placin...

Background: The Slc4 family of bicarbonate transporters consists of several members, many of which are highly expressed in the kidney and play an important role in acid-base homeostasis. Among them are Ae1 (Slc4a1) and Ae2 (Slc4a2). Another member, Ae3 (Slc4a3), is suggested to be expressed in the kidney, however, its localization and impact on renal function is still unknown. Ae3 has also been...

Introduction. Gitelman's syndrome (GS) is autosomal recessive renal tubular disorder characterized by hypokalemia, hypomagnesemia, hypocalciuria, metabolic alkalosis, and hyperreninemic hyperaldosteronism. It is usually associated with normal serum calcium. We report a patient presented with hypocalcemic tetany, and evaluation showed Gitelman's syndrome with hypocalcemia. Case Report. A 28-year...

BACKGROUND Preliminary evidence suggests that magnesium wasting occurs in patients who are treated with epidermal-growth-factor receptor (EGFR)-targeting antibodies for colorectal cancer. The mechanism of this side-effect is unknown, and if all or a subset of patients are affected is also unclear. We aimed to assess the incidence, characteristics, and predictive factors of magnesium wasting dur...

Serial nerve conduction velocities in the peroneal and ulnar nerves have been measured in 10 patients on regular dialysis treatment over a three year period. Each patient alternated between phases on dialysis with magnesium-containing dialysate (1·5-1·7 m-equiv/l.) and phases on `magnesium-free' dialysate (0·2 m-equiv/l.). Plasma magnesium concentrations were high both pre- and post-dialysis du...

To study the ionic basis of salt sensitivity in hypertension, Tl_-, 31p-, and 'Na-nuclear magnetic resonance techniques were used to measure cytosolic free calcium (Ca1), pH (pH,), free magnesium (Mg1), and sodium (Na4) in erythrocytes of essential hypertensive subjects (n = 19). Individuals were studied for 2 mo each on low(UNaV < 50 meq/d) and high(UNaV > 200 meq/d) salt diets, with the conco...

vinelanidii. The related compounds tested, phenoxyacetic acid, phenylpropionic acid, orthoand parachlorophenoxyacetic acids, inhibited the test organism to lesser degrees. Protection from the inhibition produced by 2 x 10-2 MI phenoxyacetic acid and phenylpropionic acid was afforded by molar ratios of 1: 1 and 2: 1 respectively', magnesium to the agents. Considerable protection, though not comp...

BACKGROUND In the present study, we used Doppler velocimetry in the ophthalmic artery to evaluate the hemodynamic status of the intracranial vasculature. This is the first time in the literature that indices of ophthalmic artery Doppler sonography of women with preeclampsia were evaluated before and after the use of magnesium sulfate to prevent eclampsia. CASE PRESENTATION Indices of ophthalm...

background and objectives:    febrile convulsion is one of the most common types of seizure in childhood. its pathogenesis is unknown, so studying its cause is valuable. the purpose of this study was to determine the serum level of zinc and magnesium in children withfebrileconvulsion (f.c) (3 months to 6 years age). patients and methods: in this analytical case-control study, serum level of zin...

OBJECTIVES To determine the response of nebulized magnesium sulfate on the lung function of acetylcholine-induced asthma children. METHODS Three hundred and thirty children of asthma with positive bronchial provocation test were randomly divided into three groups: magnesium sulfate, albuterol, and a combination of magnesium sulfate and albuterol. Lung function was compared between the three g...