نتایج جستجو برای: maf
تعداد نتایج: 1574 فیلتر نتایج به سال:
Biochemical and biosynthetic evidence has been obtained which indicates that the macrophage activating factor (MAF) produced by the murine T cell hybridoma clone 24/G1, which primes macrophages for nonspecific tumoricidal activity, is a form of gamma-interferon (IFN gamma). MAF and antiviral activities were generated by the clone in proportional amounts under a variety of culture conditions. Pr...
The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 50% of human multiple myelomas. Here, we show that Maf-transforming activity is controlled by GSK-3-dependent phosphorylation and that phosphorylation by GSK-3 can increase the oncogenic activity of a prot...
Multiple colors visible to the naked eye across internal surfaces of stainless-steel 304 tubes polished with a magnetic abrasive finishing (MAF) process were investigated at varying levels magnification. The found result from microscopic colored features four different hues — green, blue, red, and yellow having irregular sizes shapes. Spectral analysis their dispersion indicates that these appe...
از دیدگاه اقتصادی، شناسایی و کمی‌سازی عدم قطعیت عیاری دارای اهمیت بالایی می‌باشد. برای کمی‌سازی عدم قطعیت می‌توان از تکنیک‌های شبیه‌سازی شرطی استفاده نمود. این روش‌‌ها، برای کانسارهای تک عنصره قابل کاربرد می‌باشند، اما در کانسارهای چند عنصره که در آن‌ها لحاظ نمودن همبستگی فضایی از اهمیت بسزایی برخوردار است، به ندرت استفاده می‌شوند. برای این منظور می‌توان از روش‌هایی نظیر شبیه‌سازی شرطی توأم...
The Maf family of proteins are a subgroup of basic region-leucine zipper (bZIP) transcription factors, which recognize a long palindromic DNA sequence [TGCTGAC(G)TCAGCA] known as the Maf recognition element (MARE). Interestingly, the functional target enhancer sequences present in the alphaA-crystallin gene contain a well-conserved half-site of MARE rather than the entire palindromic sequence. ...
Stat3 signaling is essential for the induction of RORγt and subsequent Th17 cell differentiation. However, the downstream targets of Stat3 for RORγt expression remain largely unknown. We show here that a novel isoform of Sox5, named Sox5t, is induced in Th17 cells in a Stat3-dependent manner. In vivo, T cell-specific Sox5-deficient mice exhibit impaired Th17 cell differentiation and are resista...
Determining the most promising single-nucleotide polymorphisms (SNPs) presents a challenge in genome-wide association studies, when hundreds of thousands of association tests are conducted. The power to detect genetic effects is dependent on minor allele frequency (MAF), and genome-wide association studies SNP arrays include SNPs with a wide distribution of MAFs. Therefore, it is critical to un...
BACKGROUND There are currently no biomarkers for early breast cancer patient populations at risk of bone metastasis. Identification of mediators of bone metastasis could be of clinical interest. METHODS A de novo unbiased screening approach based on selection of highly bone metastatic breast cancer cells in vivo was used to determine copy number aberrations (CNAs) associated with bone metasta...
Background: Metabolic syndrome (Mets) is partially heritable. High mobility group AT-hook1 (HMGA1), an architectural transcription factor, affects the homeostasis of glucose. The marked inter-individual differences between T2DM patients in response to oral anti-diabetic drugs have become issue for effective prescribing and dosing. objective this study was designed assess whether different SNPs ...
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